The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages
of RNA metabolism and participates in the progression of many diseases, including virus …

Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Background Hypoxia, a typical hallmark of solid tumors, exhibits an essential role in the
progression of colorectal cancer (CRC), in which the dysregulation of long non-coding RNAs …

Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …

Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …

The transcription factor nuclear factor erythroid-derived 2-like 2 (NRF2) participates in the
activation of the antioxidant cytoprotective pathway and other important physiological …

The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-
mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms …

Evasion of apoptosis is a hallmark of cancer. Bcl-2 and p53 represent two important nodes
in apoptosis signaling pathways. We find that concomitant p53 activation and Bcl-2 inhibition …

The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …

Portal vein tumor thrombus (PVTT) is strongly correlated to a poor prognosis for patients with
hepatocellular carcinoma (HCC). In this study, we uncovered a causative link between …