The observation that heart failure with reduced ejection fraction is associated with elevated
circulating levels of pro-inflammatory cytokines opened a new area of research that has …

The immune system plays a pivotal role in the initiation, development and resolution of
inflammation following insult or damage to organs. The heart is a vital organ which supplies …

The past few decades have generated growing recognition that the immune system makes
an important contribution to cardiac development, composition and function. Immune cells …

Obesity and hypertension, which often coexist, are major risk factors for heart failure and are
characterized by chronic, low-grade inflammation, which promotes adverse cardiac …

Obesity is a heterogeneous disease with different degrees of cardiovascular (CV) and
metabolic manifestations. Certain ectopic fat depots may contribute to obesity-related CV …

Inflammation not only plays a crucial role in acute ischemic cardiac injury, but also
contributes to post-infarction repair and remodeling. Traditionally, neutrophils have been …

A central feature of atherosclerosis, the most prevalent chronic vascular disease and root
cause of myocardial infarction and stroke, is leukocyte accumulation in the arterial wall …

New therapies are required to reduce myocardial infarct (MI) size and prevent the onset of
heart failure in patients presenting with acute myocardial infarction (AMI), one of the leading …

Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide,
already accounting for at least half of all cases of heart failure. As most patients with HFpEF …

Macrophages play an important role in structural cardiac remodeling and the transition to
heart failure following myocardial infarction (MI). Previous research has focused on the …