The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

Microphysiological systems (MPSs) are cellular models that replicate aspects of organ and
tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide …

The principles of cerebrospinal fluid (CSF) production, circulation and outflow and regulation
of fluid volumes and pressures in the normal brain are summarised. Abnormalities in these …

Over the last decade, it has become evident that cerebrospinal fluid (CSF) plays a pivotal
role in brain solute clearance through perivascular pathways and interactions between the …

Background Several central nervous system diseases are associated with disturbed
cerebrospinal fluid (CSF) flow patterns and have typically been characterized in vivo by …

The kinetics of amyloid beta turnover within human brain is still poorly understood. We
previously found a dramatic decline in the turnover of Aβ peptides in normal aging. It was not …

Current theories suggest that waste solutes are cleared from the brain via cerebrospinal fluid
(CSF) flow, driven by pressure pulsations of possibly both cardiac and respiratory origin. In …

Neurological disorders can manifest with altered neurofluid dynamics in different
compartments of the central nervous system. These include alterations in cerebral blood …

Background Respiration-induced pressure changes represent a powerful driving force of
CSF dynamics as previously demonstrated using flow-sensitive real-time magnetic …

Idiopathic normal pressure hydrocephalus (iNPH) is a rare neurological disorder with no
clear prevalence factors and is a significant danger to the elderly. The intracranial …