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Oncogenic SRSF3 in health and diseases
R Jia, ZM Zheng - International Journal of Biological Sciences, 2023 - pmc.ncbi.nlm.nih.gov
Serine/arginine rich splicing factor 3 (SRSF3) is an important multi-functional splicing factor,
and has attracted increasing attentions in the past thirty years. The importance of SRSF3 is …
and has attracted increasing attentions in the past thirty years. The importance of SRSF3 is …
Loss of HIF1A from pancreatic cancer cells increases expression of PPP1R1B and degradation of p53 to promote invasion and metastasis
Background & Aims Pancreatic ductal adenocarcinomas (PDACs) are hypovascular,
resulting in the up-regulation of hypoxia inducible factor 1 alpha (HIF1A), which promotes …
resulting in the up-regulation of hypoxia inducible factor 1 alpha (HIF1A), which promotes …
DARPP-32 40 years later
Abstract DARPP-32 (dopamine-and cAMP-regulated phosphoprotein with an apparent Mr of
32,000), now also known as phosphoprotein phosphatase 1 regulatory subunit 1B …
32,000), now also known as phosphoprotein phosphatase 1 regulatory subunit 1B …
Urinary exosomal mRNA detection using novel isothermal gene amplification method based on three-way junction
Exosomal messenger RNA (mRNA) has emerged as a valuable biomarker for liquid biopsy-
based disease diagnosis and prognosis due to its stability in body fluids and its biological …
based disease diagnosis and prognosis due to its stability in body fluids and its biological …
ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation
Background Small cell lung cancer (SCLC) is the most aggressive form of lung cancer, and
new molecular insights are necessary for prognostic and therapeutic advances. Methods …
new molecular insights are necessary for prognostic and therapeutic advances. Methods …
Controlling Ser/Thr protein phosphatase PP1 activity and function through interaction with regulatory subunits
Protein phosphatase 1 is a major Ser/Thr protein phosphatase activity in eukaryotic cells. It
is composed of a catalytic polypeptide (PP1C), with little substrate specificity, that interacts …
is composed of a catalytic polypeptide (PP1C), with little substrate specificity, that interacts …
DARPP-32 promotes ERBB3-mediated resistance to molecular targeted therapy in EGFR-mutated lung adenocarcinoma
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-refractory lung
adenocarcinoma (LUAD) progression is a major clinical problem. New approaches to …
adenocarcinoma (LUAD) progression is a major clinical problem. New approaches to …
[HTML][HTML] Decreased number of striatal cholinergic interneurons and motor deficits in dopamine receptor 2-expressing-cell-specific Dyt1 conditional knockout mice
DYT1 early-onset generalized torsion dystonia is a hereditary movement disorder
characterized by abnormal postures and repeated movements. It is caused mainly by a …
characterized by abnormal postures and repeated movements. It is caused mainly by a …
PP1, PKA and DARPP‐32 in breast cancer: A retrospective assessment of protein and mRNA expression
B Saidy, S Kotecha, A Butler, EA Rakha… - Journal of cellular …, 2021 - Wiley Online Library
Cyclic AMP–dependent protein kinase A (PKA) and protein phosphatase 1 (PP1) are
proteins involved in numerous essential signalling pathways that modulate physiological …
proteins involved in numerous essential signalling pathways that modulate physiological …
IKKα promotes lung adenocarcinoma growth through ERK signaling activation via DARPP-32-mediated inhibition of PP1 activity
Non-small cell lung cancer (NSCLC) accounts for 80–85% cases of lung cancer cases.
Diagnosis at advanced stages is common, after which therapy-refractory disease …
Diagnosis at advanced stages is common, after which therapy-refractory disease …