The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …

Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

METTL16 has recently been identified as an RNA methyltransferase responsible for the
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …

Circular RNAs (circRNAs) are covalently closed single-stranded RNAs without a 5′ cap
structure and a 3′ poly (A) tail typically present in linear mRNAs of eukaryotic cells …

The aminoacyl-tRNA synthetases are an essential and universally distributed family of
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …

Protein translation is a tightly regulated cellular process that is essential for gene expression
and protein synthesis. The deregulation of this process is increasingly recognized as a …

Mis-regulated epigenetic modifications in RNAs are associated with human cancers. The
transfer RNAs (tRNAs) are the most heavily modified RNA species in cells; however, little is …

Translation initiation in bacteria is frequently regulated by various structures in the 5′
untranslated region (5′ UTR). Previously, we demonstrated that G-quadruplex (G4) …

Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Biosynthesis has been a diverse toolbox to develop bioactive molecules and materials,
especially for fabricating modified peptides and their assemblies induced by enzymes …