Herpesviruses replicate their DNA and package this DNA into capsids in the nucleus. These
capsids then face substantial obstacles to their release from cells. Unlike other DNA viruses …

Herpes simplex viruses (HSV) can undergo a lytic infection in epithelial cells and a latent
infection in sensory neurons. During latency the virus persists until reactivation, which leads …

During lytic infection, the genome of herpes simplex virus 1 (HSV-1) is associated with
limited levels of histones but does not form a regular repeating nucleosomal structure …

The nuclear lamina is a major obstacle encountered by herpesvirus nucleocapsids in their
passage from the nucleus to the cytoplasm (nuclear egress). We found that the human …

We report that herpes simplex virus type 1 (HSV-1) infection leads to the recruitment of
protein kinase C (PKC) to the nuclear rim. In HEp-2 cells, PKC recruitment to the nuclear rim …

Herpesviruses must traverse the nuclear envelope to gain access to the cytoplasm and,
ultimately, to exit cells. It is believed that herpesvirus nucleocapsids enter the perinuclear …

Herpes simplex virus type-1 (HSV-1) is a neurotropic, double-stranded DNA virus that can
cause a wide variety of diseases, including many ocular pathologies. It is one of the leading …

The herpes simplex virus type 1 (HSV-1) US3 gene encodes a serine/threonine kinase that,
when inactivated, causes capsids to aggregate aberrantly between the inner and outer …

Herpes simplex virus (HSV-1) lytic infection results in global changes to the host cell
proteome and the proteins associated with host chromatin. We present a system level …

Viruses are exemplary molecular biologists and have been integral to scientific discovery for
generations. It is therefore no surprise that nuclear replicating viruses have evolved to …