Insights into glomerular filtration and albuminuria

T Benzing, D Salant - New England Journal of Medicine, 2021 - Mass Medical Soc
Glomerular Filtration and Albuminuria Chronic kidney diseases generally arise from a
disordered kidney filtration barrier within glomeruli. This review describes the roles of …

Cell biology of the glomerular podocyte

H Pavenstadt, W Kriz, M Kretzler - Physiological reviews, 2003 - journals.physiology.org
Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

[PDF][PDF] Autoantibodies targeting nephrin in podocytopathies

FE Hengel, S Dehde, M Lassé, G Zahner, L Seifert… - N Engl J Med, 2024 - sfndt.org
Le syndrome néphrotique à lésions glomérulaires minimes (LGM) et la hyalinose
segmentaire et focale (HSF) primitive sont deux pathologies glomérulaires qui entrainent un …

A molecular mechanism explaining albuminuria in kidney disease

L Butt, D Unnersjö-Jess, M Höhne, A Edwards… - Nature …, 2020 - nature.com
Mammalian kidneys constantly filter large amounts of liquid, with almost complete retention
of albumin and other macromolecules in the plasma. Breakdown of the three-layered renal …

Extracellular matrix molecules: potential targets in pharmacotherapy

H Järveläinen, A Sainio, M Koulu, TN Wight… - Pharmacological …, 2009 - Elsevier
The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …

[HTML][HTML] The podocyte's response to injury: role in proteinuria and glomerulosclerosis

SJ Shankland - Kidney international, 2006 - Elsevier
The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are
highly specialized cells. They function as a critical size and charge barrier to prevent …

Acute kidney injury and progression of diabetic kidney disease

SMW Yu, JV Bonventre - Advances in chronic kidney disease, 2018 - Elsevier
Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common
cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of …

Podocyte biology and response to injury

P Mundel, SJ Shankland - Journal of the American Society of …, 2002 - journals.lww.com
The visceral glomerular epithelial cell, also called podocyte, is a terminally differentiated cell
that lines the outer aspect of the glomerular basement membrane (GBM). It therefore forms …

The podocyte slit diaphragm—from a thin grey line to a complex signalling hub

F Grahammer, C Schell, TB Huber - Nature Reviews Nephrology, 2013 - nature.com
The architectural design of our kidneys is amazingly complex, and culminates in the 3D
structure of the glomerular filter. During filtration, plasma passes through a sieve consisting …

Hereditary proteinuria syndromes and mechanisms of proteinuria

K Tryggvason, J Patrakka… - New England Journal of …, 2006 - Mass Medical Soc
Hereditary Proteinuria Syndromes and Mechanisms of Proteinuria | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …