mTOR at the nexus of nutrition, growth, ageing and disease
GY Liu, DM Sabatini - Nature reviews Molecular cell biology, 2020 - nature.com
The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …
mTOR as a central hub of nutrient signalling and cell growth
J Kim, KL Guan - Nature cell biology, 2019 - nature.com
The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally
known as mammalian target of rapamycin) is a central cell growth regulator connecting …
known as mammalian target of rapamycin) is a central cell growth regulator connecting …
Targeting the biology of aging with mTOR inhibitors
JB Mannick, DW Lamming - Nature Aging, 2023 - nature.com
Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …
The relation between PI3K/AKT signalling pathway and cancer
Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
mTOR signaling in growth, metabolism, and disease
The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and
metabolism with environmental inputs, including nutrients and growth factors. Extensive …
metabolism with environmental inputs, including nutrients and growth factors. Extensive …
The role of mTOR signaling as a therapeutic target in cancer
NV Popova, M Jücker - International Journal of Molecular Sciences, 2021 - mdpi.com
The aim of this review was to summarize current available information about the role of
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …
PI3K and cancer: lessons, challenges and opportunities
DA Fruman, C Rommel - Nature reviews Drug discovery, 2014 - nature.com
The central role of phosphoinositide 3-kinase (PI3K) activation in tumour cell biology has
prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and …
prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and …
PI3K/AKT signaling pathway and cancer: an updated review
Despite development of novel agents targeting oncogenic pathways, matching targeted
therapies to the genetic status of individual tumors is proving to be a daunting task for …
therapies to the genetic status of individual tumors is proving to be a daunting task for …
PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment
A Guerrero-Zotano, IA Mayer, CL Arteaga - Cancer and Metastasis …, 2016 - Springer
Anti-cancer cancer-targeted therapies are designed to exploit a particular vulnerability in the
tumor, which in most cases results from its dependence on an oncogene and/or loss of a …
tumor, which in most cases results from its dependence on an oncogene and/or loss of a …