Self-assembled peptides and proteins possess tremendous potential as targeted drug
delivery systems and key applications of these well-defined nanostructures reside in anti …

The structural variability data of drug transporter (DT) are key for research on precision
medicine and rational drug use. However, these valuable data are not sufficiently covered …

Drug development (target identification, advancing drug leads to candidates for preclinical
and clinical studies) can be facilitated by genetic and genomic knowledge. Here, we review …

Interpretation of the colossal number of genetic variants identified from sequencing
applications is one of the major bottlenecks in clinical genetics, with the inference of the …

Quantification of the tolerance of protein sites to genetic variation has become a cornerstone
of variant interpretation. We hypothesize that the constraint on missense variation at …

Accurate prediction of damaging missense variants is critically important for interpreting a
genome sequence. Although many methods have been developed, their performance has …

The microbiome of the human gastrointestinal (GI)-tract is a rich and dynamic source of
microorganisms that together possess a staggering complexity and diversity. Collectively …

All proteomes contain both proteins and polypeptide segments that don't form a defined
three-dimensional structure yet are biologically active—called intrinsically disordered …

Recent advances in AI-based methods have revolutionized the field of structural biology.
Concomitantly, high-throughput sequencing and functional genomics have generated …

Network analysis has emerged as a powerful tool for examining structural biology systems.
The spatial organization of the components of a biomolecular structure has been rendered …