We hypothesize that the first step of aggregation of disordered proteins, such as α-synuclein,
is controlled by the rate of backbone reconfiguration. When reconfiguration is fast …

Misfolding and aggregation of proteins are characteristics of a range of increasingly
prevalent neurodegenerative disorders including Alzheimer's and Parkinson's diseases. In …

Amyloid has been traditionally viewed in the context of disease. However, the emerging
concept of 'functional amyloid'has taken a new direction into how we view amyloid. Recent …

Molecular dynamics (MD) simulations have been widely used to analyze dynamic
conformational equilibria of folded proteins, especially in relation to NMR observables …

We have investigated intrachain contact dynamics in unfolded cytochrome cb 562 by
monitoring heme quenching of excited ruthenium photosensitizers covalently bound to …

A geometrical model has been developed to study the unfolding of iso-1 cytochrome c. The
model draws on the crystallographic data reported for this protein. These data were used to …

Misfolding and aggregation of proteins is a characteristic of a range of neurodegenerative
disorders including Alzheimer's and Parkinson's diseases (PD). In PD and several close …

The presented doctoral research utilizes time-resolved spectroscopy to characterize protein
dynamics and folding mechanisms. We resolve millisecond-timescale folding by coupling …

Results Measurement of intramolecular diffusion requires a long-lived probe that is
quenched on contact with an efficient quencher within the same sequence. We use the …