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The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
CS Zhang, M Li, Y Wang, X Li, Y Zong, S Long… - Nature …, 2022 - nature.com
The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely
correlated with the cellular availability of glucose. When glucose levels are low, the …
correlated with the cellular availability of glucose. When glucose levels are low, the …
Regulation of TSC2 lysosome translocation and mitochondrial turnover by TSC2 acetylation status
P Marqués, J Burillo, C González-Blanco, B Jiménez… - Scientific Reports, 2024 - nature.com
Abstract Sirtuin1 (SIRT1) activity decreases the tuberous sclerosis complex 2 (TSC2) lysine
acetylation status, inhibiting the mechanistic target of rapamycin complex 1 (mTORC1) …
acetylation status, inhibiting the mechanistic target of rapamycin complex 1 (mTORC1) …
[HTML][HTML] Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice
A Rohrbach, E Caron, R Dali, M Brunner… - Molecular …, 2021 - Elsevier
Objectives Glucokinase (GCK) is critical for glucosensing. In rats, GCK is expressed in
hypothalamic tanycytes and appears to play an essential role in feeding behavior. In this …
hypothalamic tanycytes and appears to play an essential role in feeding behavior. In this …
[HTML][HTML] Single and Combined Impact of Semaglutide, Tirzepatide, and Metformin on β-Cell Maintenance and Function Under High-Glucose–High-Lipid Conditions: A …
Type 2 diabetes (T2D), the most common form, is marked by insulin resistance and β-cell
failure. β-cell dysfunction under high-glucose–high-lipid (HG-HL) conditions is a key …
failure. β-cell dysfunction under high-glucose–high-lipid (HG-HL) conditions is a key …
[PDF][PDF] Develo** Targeted Therapy for B-cell Dysfunction in Type 2 Diabetes
B Patel - 2022 - dro.deakin.edu.au
This thesis aimed to identify new treatment options for patients affected by Type 2 Diabetes.
The first approach utilised a novel tool to find new drugs for Type 2 Diabetes while the …
The first approach utilised a novel tool to find new drugs for Type 2 Diabetes while the …