Parameterization, geometric modeling, and isogeometric analysis of tricuspid valves

EL Johnson, DW Laurence, F Xu, CE Crisp… - Computer methods in …, 2021 - Elsevier
Approximately 1.6 million patients in the United States are affected by tricuspid valve
regurgitation, which occurs when the tricuspid valve does not close properly to prevent …

[HTML][HTML] Whole-heart modelling with valves in a fluid–structure interaction framework

L Feng, H Gao, X Luo - Computer Methods in Applied Mechanics and …, 2024 - Elsevier
Computational modelling of whole-heart function is a useful tool to study heart mechanics
and haemodynamics. Many existing heart models focus on electromechanical aspect …

Effects of enzyme-based removal of collagen and elastin constituents on the biaxial mechanical responses of porcine atrioventricular heart valve anterior leaflets

CJ Ross, DW Laurence, AL Echols, AR Babu, T Gu… - Acta biomaterialia, 2021 - Elsevier
The leaflets of the atrioventricular heart valves (AHVs) regulate the one-directional flow of
blood through a coordination of the extracellular matrix components, including the collagen …

Benchtop characterization of the tricuspid valve leaflet pre-strains

DW Laurence, CJ Ross, MC Hsu, A Mir, HM Burkhart… - Acta Biomaterialia, 2022 - Elsevier
The pre-strains of biological soft tissues are important when relating their in vitro and in vivo
mechanical behaviors. In this study, we present the first-of-its-kind experimental …

A computational framework for atrioventricular valve modeling using open-source software

W Wu, S Ching, SA Maas… - Journal of …, 2022 - asmedigitalcollection.asme.org
Atrioventricular valve regurgitation is a significant cause of morbidity and mortality in patients
with acquired and congenital cardiac valve disease. Image-derived computational modeling …

Ex vivo experimental characterizations for understanding the interrelationship between tissue mechanics and collagen microstructure of porcine mitral valve leaflets

DJ Fitzpatrick, K Pham, CJ Ross, LT Hudson… - Journal of the …, 2022 - Elsevier
Unidirectional blood flow in the left side of the heart is regulated by the mitral valve. To better
understand the mitral valve function, researchers have examined the structural and …

Linking collagen fiber architecture to tissue-level biaxial mechanical behaviors of porcine semilunar heart valve cusps

LT Hudson, DW Laurence, HM Lau, BT Mullins… - Journal of the …, 2022 - Elsevier
The semilunar heart valves regulate the blood flow from the ventricles to the major arteries
through the opening and closing of the scallop shaped cusps. These cusps are composed of …

An investigation of how specimen dimensions affect biaxial mechanical characterizations with CellScale BioTester and constitutive modeling of porcine tricuspid valve …

DW Laurence, S Wang, R **ao, J Qian, A Mir… - Journal of …, 2023 - Elsevier
Biaxial mechanical characterizations are the accepted approach to determine the
mechanical response of many biological soft tissues. Although several computational and …

Development and realization of an experimental bench test for synchronized small angle light scattering and biaxial traction analysis of tissues

E Vignali, E Gasparotti, L Landini, S Celi - Electronics, 2021 - mdpi.com
Insights into the mechanical and microstructural status of biological soft tissues are
fundamental in analyzing diseases. Biaxial traction is the gold standard approach for …

Biomechanics Assist Measurement, Modeling, Engineering Applications, and Clinical Decision Making in Medicine

Q Chi, P Liu, H Liang - Bioengineering, 2022 - mdpi.com
Biomechanical studies of surgeries and medical devices are usually performed with human
or animal models. Biomechanical models can quantitatively access information that is …