Recent developments in two-dimensional liquid chromatography: fundamental improvements for practical applications

BWJ Pirok, DR Stoll, PJ Schoenmakers - Analytical Chemistry, 2018 - ACS Publications
Liquid chromatography (LC) is an incredibly successful analytical separation tool. Its
versatility is unprecedented because of the many different separation modes …

Optimizing separations in online comprehensive two‐dimensional liquid chromatography

BWJ Pirok, AFG Gargano… - Journal of separation …, 2018 - Wiley Online Library
Online comprehensive two‐dimensional liquid chromatography has become an attractive
option for the analysis of complex nonvolatile samples found in various fields (eg …

[HTML][HTML] Novel technologies for metabolomics: More for less

P Miggiels, B Wouters, GJP van Westen… - TrAC Trends in …, 2019 - Elsevier
The human metabolome provides a direct physiological read-out of an individual's actual
health state and includes biomarkers that may predict disease or response to a treatment …

Recent applications of retention modelling in liquid chromatography

MJ den Uijl, PJ Schoenmakers… - Journal of …, 2021 - Wiley Online Library
Recent applications of retention modelling in liquid chromatography (2015–2020) are
comprehensively reviewed. The fundamentals of the field, which date back much longer, are …

Perspective on the future approaches to predict retention in liquid chromatography

F Gritti - Analytical Chemistry, 2021 - ACS Publications
The demand for rapid column screening, computer-assisted method development and
method transfer, and unambiguous compound identification by LC/MS analyses has pushed …

Comprehensive two-dimensional liquid chromatography

L Mondello, P Dugo, P Donato, M Herrero… - Nature Reviews …, 2023 - nature.com
Despite progress in hardware and column technology, the complexity and heterogeneity of
many samples still pose a challenge for state-of-the-art 1D liquid chromatography (LC). As …

Two-dimensional liquid chromatography in pharmaceutical analysis. Instrumental aspects, trends and applications

M Iguiniz, S Heinisch - Journal of Pharmaceutical and Biomedical Analysis, 2017 - Elsevier
The interest in two-dimensional liquid chromatography (2D-LC) has been growing up since
the last decades. This promising technique appears as a relevant solution for various …

Recent applications of chemometrics in one‐and two‐dimensional chromatography

TS Bos, WC Knol, SRA Molenaar… - Journal of separation …, 2020 - Wiley Online Library
The proliferation of increasingly more sophisticated analytical separation systems, often
incorporating increasingly more powerful detection techniques, such as high‐resolution …

Untargeted comprehensive two-dimensional liquid chromatography coupled with high-resolution mass spectrometry analysis of rice metabolome using multivariate …

M Navarro-Reig, J Jaumot, A Baglai… - Analytical …, 2017 - ACS Publications
In this work, a new strategy for the chemometric analysis of two-dimensional liquid
chromatography–high-resolution mass spectrometry (LC× LC–HRMS) data is proposed …

Map** the separation landscape in two-dimensional liquid chromatography: blueprints for efficient analysis and purification of pharmaceuticals enabled by …

DM Makey, V Shchurik, H Wang, HR Lhotka… - Analytical …, 2020 - ACS Publications
Recent developments in two-dimensional liquid chromatography (2D-LC) now make
separation and analysis of very complex mixtures achievable. Despite being such a …