Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation

JAHR Claassen, DHJ Thijssen… - Physiological …, 2021 - journals.physiology.org
Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Arterial spin labeling perfusion of the brain: emerging clinical applications

S Haller, G Zaharchuk, DL Thomas, KO Lovblad… - Radiology, 2016 - pubs.rsna.org
Arterial spin labeling (ASL) is a magnetic resonance (MR) imaging technique used to assess
cerebral blood flow noninvasively by magnetically labeling inflowing blood. In this article, the …

Machine learning framework for early MRI-based Alzheimer's conversion prediction in MCI subjects

E Moradi, A Pepe, C Gaser, H Huttunen, J Tohka… - Neuroimage, 2015 - Elsevier
Mild cognitive impairment (MCI) is a transitional stage between age-related cognitive
decline and Alzheimer's disease (AD). For the effective treatment of AD, it would be …

The use of neuroimaging techniques in the early and differential diagnosis of dementia

L Chouliaras, JT O'Brien - Molecular Psychiatry, 2023 - nature.com
Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …

A neuroradiologist's guide to arterial spin labeling MRI in clinical practice

M Grade, JA Hernandez Tamames, FB Pizzini… - Neuroradiology, 2015 - Springer
Arterial spin labeling (ASL) is a non-invasive MRI technique to measure cerebral blood flow
(CBF). This review provides a practical guide and overview of the clinical applications of …

Vascular dysfunction in Alzheimer's disease: a prelude to the pathological process or a consequence of it?

K Govindpani, LG McNamara, NR Smith… - Journal of clinical …, 2019 - mdpi.com
Alzheimer's disease (AD) is the most prevalent form of dementia. Despite decades of
research following several theoretical and clinical lines, all existing treatments for the …

Associations between vascular function and tau PET are associated with global cognition and amyloid

D Albrecht, AL Isenberg, J Stradford… - Journal of …, 2020 - Soc Neuroscience
Tau pathology and vascular dysfunction are important contributors to Alzheimer's disease
(AD), but vascular–tau associations and their effects on cognition are poorly understood. We …

Prediction and classification of Alzheimer disease based on quantification of MRI deformation

X Long, L Chen, C Jiang, L Zhang… - PloS one, 2017 - journals.plos.org
Detecting early morphological changes in the brain and making early diagnosis are
important for Alzheimer's disease (AD). High resolution magnetic resonance imaging can be …

[HTML][HTML] Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer's disease

N Zhang, ML Gordon, TE Goldberg - Neuroscience & Biobehavioral …, 2017 - Elsevier
Arterial spin labeling (ASL) magnetic resonance imaging uses arterial blood water as an
endogenous tracer to measure cerebral blood flow (CBF). In this review, based on ASL …

Ketogenic medium chain triglycerides increase brain energy metabolism in Alzheimer's disease

E Croteau, CA Castellano, MA Richard… - Journal of …, 2018 - content.iospress.com
Background: In Alzheimer's disease (AD), it is unknown whether the brain can utilize
additional ketones as fuel when they are derived from a medium chain triglyceride (MCT) …