IgA nephropathy

E Stamellou, C Seikrit, SCW Tang, P Boor… - Nature Reviews …, 2023 - nature.com
IgA nephropathy (IgAN), the most prevalent primary glomerulonephritis worldwide, carries a
considerable lifetime risk of kidney failure. Clinical manifestations of IgAN vary from …

IgA nephropathy: an interesting autoimmune kidney disease

A Rajasekaran, BA Julian, DV Rizk - The American journal of the medical …, 2021 - Elsevier
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide. It is a leading cause of chronic kidney disease and progresses to end-stage …

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

K Kiryluk, E Sanchez-Rodriguez, XJ Zhou, F Zanoni… - Nature …, 2023 - nature.com
IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …

IgA nephropathy

RJ Wyatt, BA Julian - New England Journal of Medicine, 2013 - Mass Medical Soc
IgA nephropathy is a common glomerular disease that is an important cause of kidney
failure. This review discusses advances in the therapy and understanding of the molecular …

Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens

K Kiryluk, Y Li, F Scolari, S Sanna-Cherchi, M Choi… - Nature …, 2014 - nature.com
We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the
most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals …

The pathophysiology of IgA nephropathy

H Suzuki, K Kiryluk, J Novak… - Journal of the …, 2011 - journals.lww.com
Here we discuss recent advances in understanding the biochemical, immunologic, and
genetic pathogenesis of IgA nephropathy, the most common primary glomerulonephritis …

[HTML][HTML] New developments in the genetics, pathogenesis, and therapy of IgA nephropathy

R Magistroni, VD D'Agati, GB Appel, K Kiryluk - Kidney international, 2015 - Elsevier
Recent years have brought notable progress in the field of IgA nephropathy. Here, we
highlight important new directions and latest developments, including successful discovery …

Genome-wide association study identifies susceptibility loci for IgA nephropathy

AG Gharavi, K Kiryluk, M Choi, Y Li, P Hou, J **e… - Nature …, 2011 - nature.com
We carried out a genome-wide association study of IgA nephropathy, a major cause of
kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han …

Lichen planus and lichenoid dermatoses: clinical overview and molecular basis

C Tziotzios, JYW Lee, T Brier, R Saito, CK Hsu… - Journal of the American …, 2018 - Elsevier
Deriving from the Greek word λειχήν for “tree moss” and the Latin word planus for “planar,”
lichen planus is a relatively uncommon and heterogeneous cutaneous disorder that typically …

Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis

K Kiryluk, Y Li, S Sanna-Cherchi… - PLoS …, 2012 - journals.plos.org
IgA nephropathy (IgAN), major cause of kidney failure worldwide, is common in Asians,
moderately prevalent in Europeans, and rare in Africans. It is not known if these differences …