Nucleic acid amplification free biosensors for pathogen detection

Y Chen, C Qian, C Liu, H Shen, Z Wang, J **… - Biosensors and …, 2020 - Elsevier
Efficient and rapid detection of pathogens plays an important role in food safety, disease
prevention, diagnosis and environmental monitoring. The traditional method for pathogen …

Single-cell pathogen diagnostics for combating antibiotic resistance

H Li, K Hsieh, PK Wong, KE Mach, JC Liao… - Nature Reviews …, 2023 - nature.com
Bacterial infections and antimicrobial resistance are a major cause for morbidity and
mortality worldwide. Antimicrobial resistance often arises from antimicrobial misuse, where …

Diagnosis of bloodstream infections: an evolution of technologies towards accurate and rapid identification and antibiotic susceptibility testing

KC Tjandra, N Ram-Mohan, R Abe, MM Hashemi… - Antibiotics, 2022 - mdpi.com
Bloodstream infections (BSI) are a leading cause of death worldwide. The lack of timely and
reliable diagnostic practices is an ongoing issue for managing BSI. The current gold …

[HTML][HTML] Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications

N Brodyagin, M Katkevics, V Kotikam… - Beilstein journal of …, 2021 - beilstein-journals.org
Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …

Combating antimicrobial resistance via single-cell diagnostic technologies powered by droplet microfluidics

K Hsieh, KE Mach, P Zhang, JC Liao… - Accounts of chemical …, 2021 - ACS Publications
Conspectus Antimicrobial resistance is a global threat that if left unchecked could lead to 10
million annual mortalities by 2050. One factor contributing to the rise of multi-drug-resistant …

Molecular beacon strategies for sensing purpose

N Bidar, M Amini, F Oroojalian, B Baradaran… - TrAC Trends in …, 2021 - Elsevier
The improvement of nucleic acid probes as vital molecular engineering devices will cause a
noteworthy contribution to developments in bioimaging, biosensing, and disorders …

Simultaneous ultrasensitive detection and elimination of drug-resistant bacteria by cyclometalated iridium (III) complexes

A Gupta, P Prasad, S Gupta… - ACS applied materials & …, 2020 - ACS Publications
Antimicrobial resistance has become a major threat to public health due to the rampant and
empirical use of antibiotics. Rapid diagnosis of bacteria with the desired sensitivity and …

Antibacterial peptide nucleic acids—facts and perspectives

M Wojciechowska, M Równicki, A Mieczkowski… - Molecules, 2020 - mdpi.com
Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of
antibiotics, multidrug-resistant bacteria have become a serious threat and a major global …

Droplet‐Based Single‐Cell Measurements of 16S rRNA Enable Integrated Bacteria Identification and Pheno‐Molecular Antimicrobial Susceptibility Testing from …

AM Kaushik, K Hsieh, KE Mach, S Lewis… - Advanced …, 2021 - Wiley Online Library
Empiric broad‐spectrum antimicrobial treatments of urinary tract infections (UTIs) have
contributed to widespread antimicrobial resistance. Clinical adoption of evidence‐based …

Chemically modified nucleic acids and DNA intercalators as tools for nanoparticle assembly

AF De Fazio, D Misatziou, YR Baker… - Chemical Society …, 2021 - pubs.rsc.org
The self-assembly of inorganic nanoparticles to larger structures is of great research interest
as it allows the fabrication of novel materials with collective properties correlated to the …