The European Respiratory Society (ERS) Research Seminar entitled “Pulmonary vascular
endothelium: orchestra conductor in respiratory diseases-highlights from basic research to …

Oxidative stress (OS) refers to the enhancement of oxidation and the decreased of related
antioxidant enzymes activity under pathological conditions, resulting in relatively excess …

Background: Epigenetic mechanisms are critical in the pathogenesis of pulmonary arterial
hypertension (PAH). Previous studies have suggested that hypermethylation of the BMPR2 …

Abstract Nitric oxide (NO)–cyclic 3′-5′ guanosine monophosphate (cGMP) signaling
plays a critical role on smooth muscle tone, platelet activity, cardiac contractility, renal …

Background Pulmonary arterial hypertension (PAH), Group 1 pulmonary hypertension (PH),
is a type of pulmonary vascular disease characterized by abnormal contraction and …

Pulmonary hypertension (PH) is defined by a mean pulmonary arterial pressure over 25
mmHg at rest and is diagnosed by right heart catheterization. Among the different groups of …

Pulmonary arterial hypertension (PAH) is a progressive and fatal disease without a cure.
The exact pathogenic mechanisms of PAH are complex and poorly understood, yet a …

Yearly more than 15 million babies are born premature (< 37 weeks gestational age),
accounting for more than 1 in 10 births worldwide. Lung injury caused by maternal …

Objective A growing evidence demonstrates that inflammation is a major contributor to the
pathogenesis of pulmonary arterial hypertension (PAH). However, blocking inflammation …

Voltage‐gated potassium (KV) channels are key regulators of vascular smooth muscle
contractility and vascular tone, and thus have major influence on the microcirculation. KV …