Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
[HTML][HTML] Key topics in molecular docking for drug design
Molecular docking has been widely employed as a fast and inexpensive technique in the
past decades, both in academic and industrial settings. Although this discipline has now had …
past decades, both in academic and industrial settings. Although this discipline has now had …
Opportunities for tap** into three-dimensional chemical space through a quaternary carbon
TT Talele - Journal of Medicinal Chemistry, 2020 - ACS Publications
A quaternary carbon bears four other carbon substituents or combination of four non-
hydrogen substituents at four vertices of a tetrahedron. The spirocyclic quaternary carbon …
hydrogen substituents at four vertices of a tetrahedron. The spirocyclic quaternary carbon …
Twenty years on: the impact of fragments on drug discovery
After 20 years of sometimes quiet growth, fragment-based drug discovery (FBDD) has
become mainstream. More than 30 drug candidates derived from fragments have entered …
become mainstream. More than 30 drug candidates derived from fragments have entered …
Modern advances in heterocyclic chemistry in drug discovery
New advances in synthetic methodologies that allow rapid access to a wide variety of
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …
functionalized heterocyclic compounds are of critical importance to the medicinal chemist as …
New modalities for challenging targets in drug discovery
E Valeur, SM Guéret, H Adihou… - Angewandte Chemie …, 2017 - Wiley Online Library
Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …
novel biological targets, whose modulation may enable novel therapeutic options for many …
Mudiff: Unified diffusion for complete molecule generation
Molecule generation is a very important practical problem, with uses in drug discovery and
material design, and AI methods promise to provide useful solutions. However, existing …
material design, and AI methods promise to provide useful solutions. However, existing …
Escape from Flatland 2: complexity and promiscuity
F Lovering - MedChemComm, 2013 - pubs.rsc.org
Toxicity plays a major role in attrition in the clinic and promiscuity has been linked to toxicity.
A number of molecular descriptors have been identified that contribute to promiscuity …
A number of molecular descriptors have been identified that contribute to promiscuity …
Designing antimicrobial peptides: form follows function
Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …
Polypharmacology–foe or friend?
JU Peters - Journal of medicinal chemistry, 2013 - ACS Publications
Polypharmacology describes the activity of compounds at multiple targets. Current research
focuses on two aspects of polypharmacology:(1) unintended polypharmacology can lead to …
focuses on two aspects of polypharmacology:(1) unintended polypharmacology can lead to …
[HTML][HTML] Choose and use your chemical probe wisely to explore cancer biology
J Blagg, P Workman - Cancer cell, 2017 - cell.com
Small-molecule chemical probes or tools have become progressively more important in
recent years as valuable reagents to investigate fundamental biological mechanisms and …
recent years as valuable reagents to investigate fundamental biological mechanisms and …