Microscopic evolution at the functional biomolecular level is an ongoing process.
Leveraging functional and high-throughput assays, along with computational data mining …

Proteolysis targeting chimeras (PROTACs) are bifunctional compounds that recruit an E3
ligase to a target protein to induce ubiquitination and degradation of the target. Rational …

The foundation of all biological processes is the network of diverse and dynamic protein
interactions with other molecules in cells known as the interactome. Understanding the …

The low reduction potentials required for the reduction of dinitrogen (N2) render metal-
based nitrogen-fixation catalysts vulnerable to irreversible damage by dioxygen (O2) …

Branching enzymes (BEs) confer to α-glucans, the primary energy-storage reservoir in
nature, a variety of features, like slow digestion. The full catalytic cycle of BEs can be divided …

Peptide drugs play an essential role in modern therapeutics, but the computational design of
these molecules is hindered by several challenges. Traditional methods like molecular …

Bacterial infection reprograms cellular metabolism and epigenetic status, but how the
metabolic-epigenetic crosstalk empowers host antibacterial defense remains unclear. Here …

This study evaluates the performance of various structure prediction tools and molecular
docking platforms for therapeutic peptides targeting coronary artery disease (CAD) …

SARS-CoV-2 is from the enveloped virus family responsible for the COVID-19 pandemic. No
efficient drugs are currently available to treat infection explicitly caused by this virus …

Future pandemic threats may be caused by novel coronaviruses and influenza A viruses.
Here we show that when directly added to a cell culture, 12mer guanine RNA (G12) and its …