Fail-safe genetic codes designed to intrinsically contain engineered organisms

J Calles, I Justice, D Brinkley, A Garcia… - Nucleic Acids …, 2019 - academic.oup.com
One challenge in engineering organisms is taking responsibility for their behavior over many
generations. Spontaneous mutations arising before or during use can impact heterologous …

Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions

JA Escudero, A Nivina, HE Kemble, C Loot, O Tenaillon… - Elife, 2020 - elifesciences.org
Molecular examples of evolutionary innovation are scarce and generally involve point
mutations. Innovation can occur through larger rearrangements, but here experimental data …

Structural stability of the integron synaptic complex

MSE Vorobevskaia - 2024 - tud.qucosa.de
Abstract (DE) Das vorherrschende Anpassungsmittel bei gramnegativen Bakterien ist ein
genetisches System, das Integron genannt wird. Es ordnet Genkassetten neu an und fördert …

[Књига][B] Engineering Genetic Codes to Control the Evolution of So-Encoded Biological Systems

JE Calles - 2023 - search.proquest.com
All life on Earth reads DNA into proteins using the same genetic code or a close variant. But
what if it didn't? Here, I introduce a theory of genetic codes and their effect on the evolution …

Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions

JA Escudero García-Calderón, A Nivina, HE Kemble… - 2020 - docta.ucm.es
Molecular examples of evolutionary innovation are scarce and generally involve point
mutations. Innovation can occur through larger rearrangements, but here experimental data …

Synthetic Genetic Codes Designed to Hinder Evolution

J Calles, I Justice, D Brinkley, A Garcia, D Endy - bioRxiv, 2019 - biorxiv.org
One challenge in engineering organisms is guaranteeing system behavior over many
generations. Spontaneous mutations that arise before or during use can impact …