Dynamics and specificities of T cells in cancer immunotherapy
G Oliveira, CJ Wu - Nature Reviews Cancer, 2023 - nature.com
Recent advances in cancer immunotherapy—ranging from immune-checkpoint blockade
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …
High-throughput and single-cell T cell receptor sequencing technologies
T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
Guidelines for the use of flow cytometry and cell sorting in immunological studies
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …
immunology and flow cytometry community. They provide the theory and key practical …
SARS-CoV-2 genome-wide T cell epitope map** reveals immunodominance and substantial CD8+ T cell activation in COVID-19 patients
SK Saini, DS Hersby, T Tamhane, HR Povlsen… - Science …, 2021 - science.org
T cells are important for effective viral clearance, elimination of virus-infected cells, and long-
term disease protection. To examine the full spectrum of CD8+ T cell immunity in COVID-19 …
term disease protection. To examine the full spectrum of CD8+ T cell immunity in COVID-19 …
Cancer neoantigens
Malignant transformation of cells depends on accumulation of DNA damage. Over the past
years we have learned that the T cell–based immune system frequently responds to the …
years we have learned that the T cell–based immune system frequently responds to the …
NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data
Prediction of T-cell receptor (TCR) interactions with MHC-peptide complexes remains highly
challenging. This challenge is primarily due to three dominant factors: data accuracy, data …
challenging. This challenge is primarily due to three dominant factors: data accuracy, data …
Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening
CD4+ T cells are critical to fighting pathogens, but a comprehensive analysis of human T-
cell specificities is hindered by the diversity of HLA alleles (> 20,000) and the complexity of …
cell specificities is hindered by the diversity of HLA alleles (> 20,000) and the complexity of …
VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium
Here, we report an update of the VDJdb database with a substantial increase in the number
of T-cell receptor (TCR) sequences and their cognate antigens. The update further provides …
of T-cell receptor (TCR) sequences and their cognate antigens. The update further provides …
Promises and challenges of adoptive T-cell therapies for solid tumours
Cancer is a leading cause of death worldwide and, despite new targeted therapies and
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …
Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states
Suboptimal immunity to SARS-CoV-2 mRNA vaccination has frequently been observed in
individuals with various immunodeficiencies. Given the increased antibody evasion …
individuals with various immunodeficiencies. Given the increased antibody evasion …