Human autoimmunity against elements conferring protective immunity can be symbolized by
the 'ouroboros', a snake eating its own tail. Underlying infection is autoimmunity against …

Infectious diseases are commonly implicated as potential initiators of autoimmune diseases
(ADs) and represent the most commonly known factor in the development of autoimmunity in …

Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause
encephalitis in< 1% of infected individuals. We show that∼ 35% of patients hospitalized for …

Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19
pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring …

Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …

Autoantibodies neutralizing type I interferons (IFN-Is) can underlie infection severity. Here,
we trace the development of these autoantibodies at high-resolution using longitudinal …

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19
pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients …

To provide a comprehensive systematic review and meta‐analysis regarding the cumulative
incidence (incidence proportion) of human herpesvirus (HHV) reactivation among patients …

We describe humans with rare biallelic loss-of-function PTCRA variants impairing pre–α T
cell receptor (pre-TCRα) expression. Low circulating naive αβ T cell counts at birth persisted …

Abstract Objectives Type-I interferons (IFNs-I) have potent antiviral effects. IFNs-I are also
overproduced in patients with systemic lupus erythematosus (SLE). Autoantibodies (AAbs) …