β-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward
β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial
agents for treating both Gram-negative and Gram-positive bacterial infections. The β-lactam …
agents for treating both Gram-negative and Gram-positive bacterial infections. The β-lactam …
metaFlye: scalable long-read metagenome assembly using repeat graphs
Long-read sequencing technologies have substantially improved the assemblies of many
isolate bacterial genomes as compared to fragmented short-read assemblies. However …
isolate bacterial genomes as compared to fragmented short-read assemblies. However …
A critical review on the environmental application of lipopeptide micelles
The importance of lipopeptide micelles in environmental applications has been highlighted.
These vessels exhibit various sizes, shapes, and surface properties under different …
These vessels exhibit various sizes, shapes, and surface properties under different …
Natural products acting against S. aureus through membrane and cell wall disruption
G Kumar, K Engle - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2015 to 2022 Staphylococcus aureus (S. aureus) is responsible for several
community and hospital-acquired infections with life-threatening complications such as …
community and hospital-acquired infections with life-threatening complications such as …
[HTML][HTML] Challenges and opportunities in bringing nonbiological atoms to life with synthetic metabolism
R Haas, PI Nikel - Trends in Biotechnology, 2023 - cell.com
The relatively narrow spectrum of chemical elements within the microbial 'biochemical
palate'limits the reach of biotechnology, because several added-value compounds can only …
palate'limits the reach of biotechnology, because several added-value compounds can only …
Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway
Bacterial natural products have been a rich source of bioactive compounds for drug
development, and advances in DNA sequencing, informatics and molecular biology have …
development, and advances in DNA sequencing, informatics and molecular biology have …
Biosynthetic incorporation of fluorinated amino acids into the nonribosomal peptide gramicidin S
M Müll, F Pourmasoumi, L Wehrhan… - RSC Chemical …, 2023 - pubs.rsc.org
Fluorine is a key element in medicinal chemistry, as it can significantly enhance the
pharmacological properties of drugs. In this study, we aimed to biosynthetically produce …
pharmacological properties of drugs. In this study, we aimed to biosynthetically produce …
Synthetic Studies towards the Calcium‐Dependent Lipopeptide Antibiotic Cadaside B
N Kovalenko, JA Swain, GK Howard… - … A European Journal, 2022 - Wiley Online Library
In the current global crisis of antimicrobial resistance, antimicrobial peptides represent a
promising source of alternative antibiotics. Recently discovered cadaside B, a novel calcium …
promising source of alternative antibiotics. Recently discovered cadaside B, a novel calcium …
The Secondary Metabolites and Biosynthetic Diversity From Aspergillus ochraceus
L Chen, E Li, W Wu, G Wang, J Zhang, X Guo… - Frontiers in …, 2022 - frontiersin.org
Aspergillus ochraceus, generally known as a food spoilage fungus, is the representative
species in Aspergillus section Circumdati. A. ochraceus strains are widely distributed in …
species in Aspergillus section Circumdati. A. ochraceus strains are widely distributed in …
Screening strategies for biosurfactant discovery
The isolation and screening of bacteria and fungi for the production of surface-active
compounds has been the basis for the majority of the biosurfactants discovered to date …
compounds has been the basis for the majority of the biosurfactants discovered to date …