β-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward

L Narendrakumar, M Chakraborty, S Kumari… - Frontiers in …, 2023 - frontiersin.org
β-lactam antibiotics are one of the most widely used and diverse classes of antimicrobial
agents for treating both Gram-negative and Gram-positive bacterial infections. The β-lactam …

metaFlye: scalable long-read metagenome assembly using repeat graphs

M Kolmogorov, DM Bickhart, B Behsaz, A Gurevich… - Nature …, 2020 - nature.com
Long-read sequencing technologies have substantially improved the assemblies of many
isolate bacterial genomes as compared to fragmented short-read assemblies. However …

A critical review on the environmental application of lipopeptide micelles

Z Zhu, B Zhang, Q Cai, Y Cao, J Ling, K Lee… - Bioresource …, 2021 - Elsevier
The importance of lipopeptide micelles in environmental applications has been highlighted.
These vessels exhibit various sizes, shapes, and surface properties under different …

Natural products acting against S. aureus through membrane and cell wall disruption

G Kumar, K Engle - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2015 to 2022 Staphylococcus aureus (S. aureus) is responsible for several
community and hospital-acquired infections with life-threatening complications such as …

[HTML][HTML] Challenges and opportunities in bringing nonbiological atoms to life with synthetic metabolism

R Haas, PI Nikel - Trends in Biotechnology, 2023 - cell.com
The relatively narrow spectrum of chemical elements within the microbial 'biochemical
palate'limits the reach of biotechnology, because several added-value compounds can only …

Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway

LJ Stevenson, J Bracegirdle, L Liu, AV Sharrock… - RSC Chemical …, 2021 - pubs.rsc.org
Bacterial natural products have been a rich source of bioactive compounds for drug
development, and advances in DNA sequencing, informatics and molecular biology have …

Biosynthetic incorporation of fluorinated amino acids into the nonribosomal peptide gramicidin S

M Müll, F Pourmasoumi, L Wehrhan… - RSC Chemical …, 2023 - pubs.rsc.org
Fluorine is a key element in medicinal chemistry, as it can significantly enhance the
pharmacological properties of drugs. In this study, we aimed to biosynthetically produce …

Synthetic Studies towards the Calcium‐Dependent Lipopeptide Antibiotic Cadaside B

N Kovalenko, JA Swain, GK Howard… - … A European Journal, 2022 - Wiley Online Library
In the current global crisis of antimicrobial resistance, antimicrobial peptides represent a
promising source of alternative antibiotics. Recently discovered cadaside B, a novel calcium …

The Secondary Metabolites and Biosynthetic Diversity From Aspergillus ochraceus

L Chen, E Li, W Wu, G Wang, J Zhang, X Guo… - Frontiers in …, 2022 - frontiersin.org
Aspergillus ochraceus, generally known as a food spoilage fungus, is the representative
species in Aspergillus section Circumdati. A. ochraceus strains are widely distributed in …

Screening strategies for biosurfactant discovery

M Trindade, N Sithole, S Kubicki, S Thies… - Biosurfactants for the …, 2021 - Springer
The isolation and screening of bacteria and fungi for the production of surface-active
compounds has been the basis for the majority of the biosurfactants discovered to date …