Bioactive compounds in oxidative stress-mediated diseases: targeting the NRF2/ARE signaling pathway and epigenetic regulation

M Thiruvengadam, B Venkidasamy, U Subramanian… - Antioxidants, 2021‏ - mdpi.com
Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …

Oxidative stress and cancer: the role of Nrf2

S Sajadimajd, M Khazaei - Current cancer drug targets, 2018‏ - benthamdirect.com
Oxidative stress due to imbalance between ROS production and detoxification plays a
pivotal role in determining cell fate. In response to the excessive ROS, apoptotic signaling …

Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers

K Chen, P Lu, NM Beeraka, OA Sukocheva… - Seminars in cancer …, 2022‏ - Elsevier
Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-develo**
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

The science behind microgreens as an exciting new food for the 21st century

U Choe, LL Yu, TTY Wang - Journal of agricultural and food …, 2018‏ - ACS Publications
Chronic diseases are a major health problem in the United States. Accumulated data
suggest that consumption of vegetables can significantly reduce the risk of many chronic …

Regulation of Nrf2—an update

SK Niture, R Khatri, AK Jaiswal - Free Radical Biology and Medicine, 2014‏ - Elsevier
Abstract Nrf2: INrf2 (Keap1) are cellular sensors of oxidative and electrophilic stress. Nrf2 is
a nuclear factor that controls the expression and coordinated induction of a battery of genes …

Gamma-tocopherol, a major form of vitamin E in diets: Insights into antioxidant and anti-inflammatory effects, mechanisms, and roles in disease management

Q Jiang, S Im, JG Wagner, ML Hernandez… - Free Radical Biology and …, 2022‏ - Elsevier
Abstract γ-Tocopherol (γT) is a major form of vitamin E in the US diet and the second most
abundant vitamin E in the blood and tissues, while α-tocopherol (αT) is the predominant …

[HTML][HTML] Redox toxicology of environmental chemicals causing oxidative stress

F Zheng, FM Gonçalves, Y Abiko, H Li, Y Kumagai… - Redox biology, 2020‏ - Elsevier
Living organisms are surrounded with heavy metals such as methylmercury, manganese,
cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or …

[HTML][HTML] Vitamin E beyond its antioxidant label

A Ungurianu, A Zanfirescu, G Nițulescu, D Margină - Antioxidants, 2021‏ - mdpi.com
Vitamin E, comprising tocopherols and tocotrienols, is mainly known as an antioxidant. The
aim of this review is to summarize the molecular mechanisms and signaling pathways linked …

[HTML][HTML] Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2

B Bathish, H Robertson, JF Dillon… - Free Radical Biology …, 2022‏ - Elsevier
Non-alcoholic steatohepatitis (NASH) represents a global health concern. It is characterised
by fatty liver, hepatocyte cell death and inflammation, which are associated with lipotoxicity …

The complexity of the Nrf2 pathway: beyond the antioxidant response

Y Huang, W Li, Z Su, ANT Kong - The Journal of nutritional biochemistry, 2015‏ - Elsevier
The NF-E2-related factor 2 (Nrf2)-mediated signalling pathway provides living organisms an
efficient and pivotal line of defensive to counteract environmental insults and endogenous …