PU. 1 is an ETS-family transcription factor that plays a broad range of roles in
hematopoiesis. A direct regulator of myeloid, dendritic-cell, and B cell functional programs …

The identification of distinct waves of progenitors during development, each corresponding
to a specific time, space and function provided the basis for the concept of a “layered” …

Whereas the critical roles of innate lymphoid cells (ILCs) in adult are increasingly
appreciated, their developmental hierarchy in early human fetus remains largely elusive. In …

Abstract Innate Lymphoid Cells (ILC) are involved in homeostasis and immunity. Their
dynamic differentiation and characterization depend on their tissue of residency and is …

During embryonic development, multiple waves of hematopoietic progenitors with distinct
lineage potential are differentially regulated in time and space. Two different waves of thymic …

T cells develop from multipotent progenitors by a gradual process dependent on intrathymic
Notch signaling and coupled with extensive proliferation. The stages leading them to T-cell …

Hematopoietic stem cells (HSCs) generated during embryonic development are able to
maintain hematopoiesis for the lifetime, producing all mature blood lineages. HSC …

T‐cell differentiation is a tightly regulated developmental program governed by interactions
between transcription factors (TFs) and chromatin landscapes and affected by signals …

Mammalian T cell development initiates from the migration of hematopoietic progenitors to
the thymus, which undergo cell proliferation, T-lineage specification and commitment, as …

Highlights•Single-cell transcriptome analyses reveal homology of mouse and human T-cell
programs.•T-Cell precursors begin the T program from a multipotent progenitor-like …