Ankylosing spondylitis and axial spondyloarthritis

JD Taurog, A Chhabra, RA Colbert - New England Journal of …, 2016 - Mass Medical Soc
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IL-17 in the immunopathogenesis of spondyloarthritis

LS Taams, KJA Steel, U Srenathan, LA Burns… - Nature reviews …, 2018 - nature.com
Spondyloarthritis (SpA) is a term that refers to a group of inflammatory diseases that includes
psoriatic arthritis, axial SpA and nonradiographic axial SpA, reactive arthritis, enteropathic …

Interleukin‐17A inhibition diminishes inflammation and new bone formation in experimental spondyloarthritis

MN van Tok, LM van Duivenvoorde… - Arthritis & …, 2019 - Wiley Online Library
Objective It remains unclear if and how inflammation and new bone formation in
spondyloarthritis (SpA) are coupled. We undertook this study to assess the hypothesis that …

CXCL12/CXCR4-Rac1–mediated migration of osteogenic precursor cells contributes to pathological new bone formation in ankylosing spondylitis

H Cui, Z Li, S Chen, X Li, D Chen, J Wang, Z Li… - Science …, 2022 - science.org
Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by inflammatory
back pain and spinal ankylosis due to pathological new bone formation. Here, we identified …

Pathophysiology, assessment and treatment of psoriatic dactylitis

D McGonagle, AL Tan, A Watad… - Nature Reviews …, 2019 - nature.com
Dactylitis is diffuse swelling of the digits that is usually related to an underlying inflammatory
or infiltrative disorder. Psoriatic arthritis (PsA) is the most common severe disease thought to …

Piezo1-mediated mechanotransduction promotes entheseal pathological new bone formation in ankylosing spondylitis

S Chen, Z Li, D Chen, H Cui, J Wang, Z Li, X Li… - Annals of the Rheumatic …, 2023 - Elsevier
Objective The aim of this study was to identify the role of Piezo1-mediated
mechanotransduction in entheseal pathological new bone formation and to explore the …

Anti-IL-17 agents in the treatment of axial spondyloarthritis

F Atzeni, A Carriero, L Boccassini… - ImmunoTargets and …, 2021 - Taylor & Francis
Axial spondyloarthritis (axSpA) describes a group of chronic inflammatory rheumatic
diseases primarily involving the axial skeleton. IL-17 is involved in the pathogenesis of …

Transmembrane TNF drives osteoproliferative joint inflammation reminiscent of human spondyloarthritis

MH Kaaij, MN van Tok, IC Blijdorp… - Journal of Experimental …, 2020 - rupress.org
TNF plays a key role in immune-mediated inflammatory diseases including rheumatoid
arthritis (RA) and spondyloarthritis (SpA). It remains incompletely understood how TNF can …

[HTML][HTML] Psoriatic dactylitis: current perspectives and new insights in ultrasonography and magnetic resonance imaging

N Girolimetto, I Giovannini, G Crepaldi… - Journal of clinical …, 2021 - mdpi.com
Dactylitis, one of the most typical features of psoriatic arthritis (PsA), is the diffuse swelling of
the digits and is determined by the involvement of different anatomic structures, including …

Tofacitinib for the treatment of active ankylosing spondylitis in adults

R Mohanakrishnan, S Beier… - Expert Review of Clinical …, 2022 - Taylor & Francis
Introduction Ankylosing spondylitis, also known as radiographic axial spondyloarthritis, is a
complex, immune-mediated inflammatory disorder most commonly involving the spine …