Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …

The aging process is characterized by the chronic inflammatory status called
“inflammaging”, which shares major molecular and cellular features with the metabolism …

The first paper on “inflammaging” published in 2001 paved the way for a unifying theory on
how and why aging turns out to be the main risk factor for the development of the most …

Major depressive disorder (MDD) is characterized by psychological and physiological
manifestations contributing to the disease severity and outcome. In recent years, several …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is characterized
by a high mortality of elderly men with age-related comorbidities. In most of these patients …

Single-cell gene expression (transcriptomics) data are becoming robust and abundant, and
are increasingly used to track organisms along their life-course. This allows investigation …

Osteoarthritis (OA) is the most common age-related chronic and disabling joint disease.
Long considered to be a “wear and tear” disease, OA is now seen as a low-grade …

During Inflammaging, a dysregulation of the immune cell functions is generated, and these
cells acquire a senescent phenotype with an increase in pro-inflammatory cytokines and …

Many potential immune therapeutic targets are similarly affected in adult-onset
neurodegenerative diseases, such as Alzheimer's (AD) disease, Parkinson's disease (PD) …