Evolve and resequence (E&R) experiments use experimental evolution to adapt populations
to a novel environment, then next-generation sequencing to analyse genetic changes. They …

The budding yeast Saccharomyces cerevisiae has been used in laboratory experiments for
over a century and has been instrumental in understanding virtually every aspect of …

The question of how genetic variation in a population influences phenotypic variation and
evolution is of major importance in modern biology. Yet much is still unknown about the …

Map** the genetic basis of complex traits is critical to uncovering the biological
mechanisms that underlie disease and other phenotypes. Genome-wide association studies …

Thermotolerance is a polygenic trait that contributes to cell survival and growth under
unusually high temperatures. Although some genes associated with high-temperature …

Abstract In “evolve-and-resequence”(E&R) experiments, whole-genome sequence data from
laboratory-evolved populations can potentially uncover mechanisms of adaptive change …

Abstract Loss‐of‐function (LoF) mutations associated with disease do not manifest equally
in different individuals. The impact of the genetic background on the consequences of LoF …

Adaptation from standing genetic variation is an important process underlying evolution in
natural populations, but we rarely get the opportunity to observe the dynamics of fitness and …

The capacity to map traits over large cohorts of individuals—phenomics—lags far behind the
explosive development in genomics. For microbes, the estimation of growth is the key …

Multiparental populations (MPPs) encompass greater genetic diversity than traditional
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …