Synapses, as fundamental units of the neural circuitry, enable complex behaviors. The
neuromuscular junction (NMJ) is a synapse type that forms between motoneurons and …

Acetylcholine (ACh) is stored in vesicles in the nerve terminal (Fig. 1). 1 ACh-containing
vesicles are aligned near the ACh release sites or active zones where the vesicles will fuse …

β-Catenin is a transcriptional activator shown to regulate the embryonic, postnatal, and
oncogenic growth of many tissues. In most research to date, β-catenin activation has been …

The detailed process of how dystrophic muscles are replaced by fibrotic tissues is unknown.
In the present study, the immunolocalization and mRNA expression of connective tissue …

Cyclin-dependent kinase (Cdk) 5 is a key regulator of neural development. We have
previously demonstrated that Cdk5/p35 are localized to the postsynaptic muscle and are …

The neuromuscular junction (NMJ), a cellular synapse between a motor neuron and a
skeletal muscle fiber, enables the translation of chemical cues into physical activity. The …

Motoneuron-derived agrin clusters nicotinic acetylcholine receptors (AChRs) in mammalian
muscle cells. We used two-hybrid screens to identify a protein, tumorous imaginal discs …

The release of Agrin by motoneurons activates the muscle-specific receptor tyrosine kinase
(MuSK) as the main organizer of subsynaptic specializations at the neuromuscular junction …

Neuromuscular junctions (NMJs) in mammalian skeletal muscle undergo a postnatal
topological transformation from a simple oval plaque to a complex branched structure. We …

Motoneurons are important for regulating the function and properties of skeletal muscle. In
the present study high‐density oligonucleotide arrays have been used to compare gene …