Melatonin: another avenue for treating osteoporosis?

T Li, S Jiang, C Lu, W Yang, Z Yang… - Journal of pineal …, 2019 - Wiley Online Library
Melatonin is a signal molecule that modulates the biological circadian rhythms of
vertebrates. Melatonin deficiency is thought to be associated with several disorders …

Melatonin improves therapeutic potential of mesenchymal stem cells-derived exosomes against renal ischemia-reperfusion injury in rats

FA Alzahrani - American journal of translational research, 2019 - pmc.ncbi.nlm.nih.gov
Renal ischemia-reperfusion injury (RIRI) is one of the main causes for acute kidney injury
(AKI). Many previous attempts failed to adopt a suitable treatment regimen for AKI. Recently …

Melatonin accelerates osteoporotic bone defect repair by promoting osteogenesis–angiogenesis coupling

S Zheng, C Zhou, H Yang, J Li, Z Feng… - Frontiers in …, 2022 - frontiersin.org
Previous studies have revealed that melatonin could play a role in anti-osteoporosis and
promoting osteogenesis. However, the effects of melatonin treatment on osteoporotic bone …

Mechanism and application prospect of ferroptosis inhibitors in improving osteoporosis

J Wang, TR Chen, F Gao - Frontiers in Endocrinology, 2024 - frontiersin.org
Osteoporosis, a prevalent bone metabolic disorder, has emerged as a pressing global
public health concern. Recent studies have illuminated a crucial link between ferroptosis …

Melatonin enhances osteoblastogenesis of senescent bone marrow stromal cells through NSD2‐mediated chromatin remodelling

Y **e, N Han, F Li, L Wang, G Liu, M Hu… - Clinical and …, 2022 - Wiley Online Library
Background Aging‐associated osteoporosis is frequently seen in the elderly in clinic, but
efficient managements are limited because of unclear nosogenesis. The current study aims …

Melatonin-loaded mesoporous zinc-and gallium-doped hydroxyapatite nanoparticles to control infection and bone repair

M Shokri, M Kharaziha, HA Tafti, F Dalili… - Biomaterials …, 2024 - pubs.rsc.org
Effective treatment of infected bone defects resulting from multi-drug resistant bacteria
(MDR) has emerged as a significant clinical challenge, highlighting the pressing demand for …

Melatonin-pretreated adipose-derived mesenchymal stem cells efficeintly improved learning, memory, and cognition in an animal model of Alzheimer's disease

E Nasiri, A Alizadeh, AM Roushandeh, R Gazor… - Metabolic brain …, 2019 - Springer
Currently, mesenchymal stem cells (MSCs) based therapy has extensive attraction for
Alzheimer's disease (AD). However, low survival rate of MSCs after transplantation is a huge …

Antioxidant preconditioning improves therapeutic outcomes of adipose tissue-derived mesenchymal stem cells through enhancing intrahepatic engraftment efficiency …

N Liao, Y Shi, Y Wang, F Liao, B Zhao, Y Zheng… - Stem cell research & …, 2020 - Springer
Background Although it has been preclinically suggested that adipose tissue-derived
mesenchymal stem cell (ADSC)-based therapy could effectively treat chronic liver diseases …

Therapeutic effects of melatonin-treated bone marrow mesenchymal stem cells (BMSC) in a rat model of Alzheimer's disease

M Ramezani, A Komaki, N Hashemi-Firouzi… - Journal of Chemical …, 2020 - Elsevier
The therapy based on mesenchymal stem cells (MSCs) has received growing attraction for
Alzheimer's disease (AD). However, a great challenge in this regard is the low survival rate …

Effects of melatonin-pretreated adipose-derived mesenchymal stem cells (MSC) in an animal model of spinal cord injury

A Naeimi, A Zaminy, N Amini, R Balabandi… - BMC neuroscience, 2022 - Springer
Background One of the most serious nervous system diseases is spinal cord injury (SCI),
which is increasing for various reasons. Although no definitive treatment has yet been …