To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones
mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the …

Summary The Cdk-Rb-E2F pathway integrates external and internal signals to control
progression at the G1/S transition of the mammalian cell cycle. Alterations in this pathway …

Although metabolism plays an active role in antibiotic lethality, antibiotic resistance is
generally associated with drug target modification, enzymatic inactivation, and/or transport …

Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …

Adaptation by natural selection depends on the rates, effects and interactions of many
mutations, making it difficult to determine what proportion of mutations in an evolving lineage …

Microbiome research has increased dramatically in recent years, driven by advances in
technology and significant reductions in the cost of analysis. Such research has unlocked a …

The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …

Our understanding of cancer is being transformed by exploring clonal diversity, drug
resistance, and causation within an evolutionary framework. The therapeutic resilience of …

DNA-amplicon-based microbiota profiling can estimate species diversity and abundance but
cannot resolve genetic differences within individuals of the same species. Here we report …

Predictive biology is the next great chapter in synthetic and systems biology, particularly for
microorganisms. Tasks that once seemed infeasible are increasingly being realized such as …