Alzheimer's disease is characterized by sustained neuroinflammation leading to memory
loss and cognitive decline. The past decade has witnessed tremendous efforts in …

Abstract Interleukin-33 (IL-33)—a member of the IL-1 family—was originally described as an
inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now …

Abstract Background Interleukin-1 beta (IL-1β) and its key regulator, the inflammasome, are
suspected to play a role in the neuroinflammation observed in Alzheimer's disease (AD); no …

Alzheimer's disease (AD) is a devastating condition with no known effective treatment. AD is
characterized by memory loss as well as impaired locomotor ability, reasoning, and …

Microglia are activated in response to a number of different pathological states within the
CNS including injury, ischemia, and infection. Microglial activation results in their production …

The role of the cytokines and receptors of the IL-1 family in inflammation is well known.
Several cytokines of the family have a powerful inflammatory activity, with IL-1β being the …

Inflammation is a prominent feature of CNS injury that heavily influences neuronal survival,
yet the signals that initiate and control it remain poorly understood. Here we identify the …

Abstract Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by
many cell types following pro-inflammatory stimulation and is thought to be released on cell …

The immune system is now considered a major factor in Alzheimer Disease (AD). This
review seeks to demonstrate how various aspects of the immune system, both in the brain …

IL-33 (previously known as NF from high endothelial venules) is an IL-1 family cytokine that
signals through the ST2 receptor and drives cytokine production in mast cells, basophils …