The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain

CA Warwick, AL Keyes, TM Woodruff… - Journal of Biological …, 2021 - jbc.org
The complement cascade is a key component of the innate immune system that is rapidly
recruited through a cascade of enzymatic reactions to enable the recognition and clearance …

Neutrophils—from bone marrow to first-line defense of the innate immune system

RF Kraus, MA Gruber - Frontiers in immunology, 2021 - frontiersin.org
Neutrophils (polymorphonuclear cells; PMNs) form a first line of defense against pathogens
and are therefore an important component of the innate immune response. As a result of …

Structural biology of complement receptors

J Santos-López, K de la Paz, FJ Fernández… - Frontiers in …, 2023 - frontiersin.org
The complement system plays crucial roles in a wide breadth of immune and inflammatory
processes and is frequently cited as an etiological or aggravating factor in many human …

FDA's stamp of approval: Unveiling peptide breakthroughs in cardiovascular diseases, ACE, HIV, CNS, and beyond

O Al Musaimi - Journal of Peptide Science, 2024 - Wiley Online Library
Peptides exhibit significant specificity and effective interaction with therapeutic targets,
positioning themselves as key players in the global pharmaceutical market. They offer …

Zika virus infection induces Interleukin-1β-Mediated Inflammatory responses by macrophages in the brain of an adult mouse model

GU Jeong, S Lee, DY Kim, J Lyu, GY Yoon… - Journal of …, 2023 - journals.asm.org
ABSTRACT During the 2015–2016 Zika virus (ZIKV) epidemic, ZIKV-associated
neurological diseases were reported in adults, including microcephaly, Guillain-Barre …

Sensory neuron dysfunction in orthotopic mouse models of colon cancer

M Balogh, J Zhang, CM Gaffney, N Kalakuntla… - Journal of …, 2022 - Springer
Reports of neurological sequelae related to colon cancer are largely restricted to rare
instances of paraneoplastic syndromes, due to autoimmune reactions. Systemic …

Aspirin-triggered Resolvin D1 ameliorates activation of the NLRP3 inflammasome via induction of autophagy in a rat model of neuropathic pain

YH Wang, YR Tang, X Gao, NN Zhang, QQ Lv… - Frontiers in …, 2023 - frontiersin.org
Background: Several studies performed thus far indicate that neuroinflammation may be one
of the mechanisms underlying the pathogenesis of neuropathic pain (NP). Autophagy, as an …

[HTML][HTML] Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy

C Cristiano, C Giorgio, P Cocchiaro, S Boccella… - Cytokine, 2023 - Elsevier
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of several
antitumor agents resulting in progressive and often irreversible damage of peripheral …

The role of C5a receptors in autoimmunity

J Schanzenbacher, KH Kähler, E Mesler, M Kleingarn… - Immunobiology, 2023 - Elsevier
The complement system is an essential component of the innate immune response and
plays a vital role in host defense and inflammation. Dysregulation of the complement system …

Emerging approaches for the management of chemotherapy-induced peripheral neuropathy (CIPN): Therapeutic potential of the C5a/C5aR Axis

MC Spera, MC Cesta, M Zippoli, G Varrassi… - Pain and Therapy, 2022 - Springer
Chemotherapy-induced peripheral neuropathy (CIPN) is the most common neurologic
complication of chemotherapy, resulting in symptoms like pain, sensory loss, and numbness …