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The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain
The complement cascade is a key component of the innate immune system that is rapidly
recruited through a cascade of enzymatic reactions to enable the recognition and clearance …
recruited through a cascade of enzymatic reactions to enable the recognition and clearance …
Neutrophils—from bone marrow to first-line defense of the innate immune system
RF Kraus, MA Gruber - Frontiers in immunology, 2021 - frontiersin.org
Neutrophils (polymorphonuclear cells; PMNs) form a first line of defense against pathogens
and are therefore an important component of the innate immune response. As a result of …
and are therefore an important component of the innate immune response. As a result of …
Structural biology of complement receptors
J Santos-López, K de la Paz, FJ Fernández… - Frontiers in …, 2023 - frontiersin.org
The complement system plays crucial roles in a wide breadth of immune and inflammatory
processes and is frequently cited as an etiological or aggravating factor in many human …
processes and is frequently cited as an etiological or aggravating factor in many human …
FDA's stamp of approval: Unveiling peptide breakthroughs in cardiovascular diseases, ACE, HIV, CNS, and beyond
O Al Musaimi - Journal of Peptide Science, 2024 - Wiley Online Library
Peptides exhibit significant specificity and effective interaction with therapeutic targets,
positioning themselves as key players in the global pharmaceutical market. They offer …
positioning themselves as key players in the global pharmaceutical market. They offer …
Zika virus infection induces Interleukin-1β-Mediated Inflammatory responses by macrophages in the brain of an adult mouse model
ABSTRACT During the 2015–2016 Zika virus (ZIKV) epidemic, ZIKV-associated
neurological diseases were reported in adults, including microcephaly, Guillain-Barre …
neurological diseases were reported in adults, including microcephaly, Guillain-Barre …
Sensory neuron dysfunction in orthotopic mouse models of colon cancer
Reports of neurological sequelae related to colon cancer are largely restricted to rare
instances of paraneoplastic syndromes, due to autoimmune reactions. Systemic …
instances of paraneoplastic syndromes, due to autoimmune reactions. Systemic …
Aspirin-triggered Resolvin D1 ameliorates activation of the NLRP3 inflammasome via induction of autophagy in a rat model of neuropathic pain
YH Wang, YR Tang, X Gao, NN Zhang, QQ Lv… - Frontiers in …, 2023 - frontiersin.org
Background: Several studies performed thus far indicate that neuroinflammation may be one
of the mechanisms underlying the pathogenesis of neuropathic pain (NP). Autophagy, as an …
of the mechanisms underlying the pathogenesis of neuropathic pain (NP). Autophagy, as an …
[HTML][HTML] Inhibition of C5aR1 as a promising approach to treat taxane-induced neuropathy
C Cristiano, C Giorgio, P Cocchiaro, S Boccella… - Cytokine, 2023 - Elsevier
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of several
antitumor agents resulting in progressive and often irreversible damage of peripheral …
antitumor agents resulting in progressive and often irreversible damage of peripheral …
The role of C5a receptors in autoimmunity
J Schanzenbacher, KH Kähler, E Mesler, M Kleingarn… - Immunobiology, 2023 - Elsevier
The complement system is an essential component of the innate immune response and
plays a vital role in host defense and inflammation. Dysregulation of the complement system …
plays a vital role in host defense and inflammation. Dysregulation of the complement system …
Emerging approaches for the management of chemotherapy-induced peripheral neuropathy (CIPN): Therapeutic potential of the C5a/C5aR Axis
Chemotherapy-induced peripheral neuropathy (CIPN) is the most common neurologic
complication of chemotherapy, resulting in symptoms like pain, sensory loss, and numbness …
complication of chemotherapy, resulting in symptoms like pain, sensory loss, and numbness …