The pathobiology of vascular dementia
C Iadecola - Neuron, 2013 - cell.com
Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …
Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel
Cognitive impairment associated with aging has emerged as one of the major public health
challenges of our time. Although Alzheimer's disease is the leading cause of clinically …
challenges of our time. Although Alzheimer's disease is the leading cause of clinically …
Neurovascular and cognitive dysfunction in hypertension: epidemiology, pathobiology, and treatment
C Iadecola, RF Gottesman - Circulation research, 2019 - Am Heart Assoc
Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …
known to be associated with dementia caused by vascular factors, hypertension has more …
Periventricular remyelination failure in multiple sclerosis: a substrate for neurodegeneration
In multiple sclerosis, spontaneous remyelination is generally incomplete and heterogeneous
across patients. A high heterogeneity in remyelination may also exist across lesions within …
across patients. A high heterogeneity in remyelination may also exist across lesions within …
Association of regional white matter hyperintensities with longitudinal Alzheimer-like pattern of neurodegeneration in older adults
Importance Small vessel cerebrovascular disease, visualized as white matter
hyperintensities (WMH), is associated with cognitive decline and risk of clinical Alzheimer …
hyperintensities (WMH), is associated with cognitive decline and risk of clinical Alzheimer …
Incident subcortical infarcts induce focal thinning in connected cortical regions
Objective: Brain atrophy is common in subcortical ischemic vascular disease, but the
underlying mechanisms are poorly understood. We set out to examine the effects of incident …
underlying mechanisms are poorly understood. We set out to examine the effects of incident …
White matter hyperintensities and longitudinal cognitive decline in cognitively normal populations and across diagnostic categories: a meta‐analysis, systematic …
Introduction The primary aim of this paper is to improve the clinical interpretation of white
matter hyperintensities (WMHs) and provide an overarching summary of methodological …
matter hyperintensities (WMHs) and provide an overarching summary of methodological …
Pathogenesis of cerebral microbleeds: in vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment
Objective Cerebral microbleeds (CMBs) are a neuroimaging marker of small vessel disease
(SVD) with relevance for understanding disease mechanisms in cerebrovascular disease …
(SVD) with relevance for understanding disease mechanisms in cerebrovascular disease …
Automatic segmentation of white matter hyperintensities in routine clinical brain MRI by 2D VB-Net: A large-scale study
W Zhu, H Huang, Y Zhou, F Shi, H Shen… - Frontiers in aging …, 2022 - frontiersin.org
White matter hyperintensities (WMH) are imaging manifestations frequently observed in
various neurological disorders, yet the clinical application of WMH quantification is limited. In …
various neurological disorders, yet the clinical application of WMH quantification is limited. In …
Gray and white matter changes linking cerebral small vessel disease to gait disturbances
Objective: To investigate the topographic changes of white matter (WM) integrity and cortical
thickness related to gait disturbances and determine whether these neural correlates …
thickness related to gait disturbances and determine whether these neural correlates …