Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators …

The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

Acute graft-versus-host disease (aGVHD) is associated with high risk of morbidity and
mortality and is a common complication after double umbilical cord blood (UCB) …

Cytokines have pivotal roles in immunity, making them attractive as therapeutics for a variety
of immune-related disorders. However, the widespread clinical use of cytokines has been …

We studied the safety and clinical outcomes of patients treated with umbilical cord blood
(UCB)-derived regulatory T cells (Tregs) that expanded in cultures stimulated with K562 …

The understanding of how chemokines orchestrate the trafficking and activity of immune
cells has increased considerably. So far, over 50 chemokines and 20 chemokine receptors …

Allogeneic hematopoietic stem cell transplantation (HSCT) has evolved into an effective
adoptive cellular immunotherapy for the treatment of a number of cancers. The …

Myeloid-derived suppressor cells (MDSCs) are a well-defined population of cells that
accumulate in the tissue of tumor-bearing animals and are known to inhibit immune …

Substantial progress in understanding the biology of regulatory T cells and their roles in
health and disease has been achieved in the past 10 years. This has led to an increasing …

To determine the site and mechanism of suppression by regulatory T (Treg) cells, we
investigated their migration and function in an islet allograft model. Treg cells first migrated …