Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

The human brain directs complex behaviors, ranging from fine motor skills to abstract
intelligence, but the diversity of cell types that support these skills has not been fully …

Oligodendrocyte precursor cells (OPCs) comprise 5–8% of the adult glial cell population and
stand out as the most proliferative cell type in the central nervous system (CNS). OPCs are …

Evidence from animal experiments has shown that the hypothalamic paraventricular nucleus
(PVN) plays a key role in regulating body weight and blood glucose levels. However, it is …

Abstract Myelin Basic Protein (MBP) is essential for both elaboration and maintenance of
CNS myelin, and its reduced accumulation results in hypomyelination. How different Mbp …

The lack of understanding of the cellular and molecular basis of clinical and genetic
heterogeneity in progressive multiple sclerosis (MS) has hindered the search for new …

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and
efficient signal transmission in the central nervous system. Recent evidence has challenged …

The molecules that constitute myelin are critical for the integrity of axon/myelin‐units and
thus speed and precision of impulse propagation. In the CNS, the protein composition of …

Poor understanding of the cellular and molecular basis of clinical and genetic heterogeneity
in progressive multiple sclerosis (MS) has hindered the search for new effective therapies …

Multiple sclerosis (MS) is the most prevalent human inflammatory disease of the central
nervous system with demyelination and glial scar formation as pathological hallmarks. Glial …