The global tuberculosis (TB) control effort is focused on interrupting transmission of the
causative agent, Mycobacterium tuberculosis, through chemotherapeutic intervention in …

Despite the importance of tuberculosis as a public health problem, we know relatively little
about the molecular mechanisms used by the causative organism, Mycobacterium …

Our understanding of Mycobacterium tuberculosis DNA repair mechanisms is still poor
compared with that of other bacterial organisms. However, the publication of the first …

Escherichia coli-mycobacterium shuttle vectors are important tools for gene expression and
gene replacement in mycobacteria. However, most of the currently available vectors are …

During colonization and disease, bacterial pathogens must survive the onslaught of the host
immune system. A key component of the innate immune response is the generation of …

The genomic integrity of Mycobacterium tuberculosis is continuously threatened by the
harsh survival conditions inside host macrophages, due to immune and antibiotic stresses …

Uracil DNA glycosylase (UDG or Ung) is a key enzyme involved in uracil excision from the
DNA as a repair mechanism. Designing Ung inhibitors is thus a promising strategy to treat …

DNA glycosylases are enzymes that initiate the base excision repair pathway, a major
biochemical process that protects the genomes of all living organisms from intrinsically and …

Uracil DNA glycosylases (UDGs) are an important group of DNA repair enzymes, which
pioneer the base excision repair pathway by recognizing and excising uracil from DNA …

Background Rifampicin resistance (RR) is a surrogate marker of multidrug-resistant
tuberculosis. The aim of this study is to determine the frequency of the commonly mutated …