Importance Clinicians, patients, and policy makers rely on published results from clinical
trials to help make evidence-informed decisions. To critically evaluate and use trial results …

Advances in quantitative biomarker development have accelerated new forms of data-driven
insights for patients with cancer. However, most approaches are limited to a single mode of …

Health economic evaluations are comparative analyses of alternative courses of action in
terms of their costs and consequences. The Consolidated Health Economic Evaluation …

Purpose To develop a set of consensus and empirically based reporting recommendations
for primary studies of the measurement properties of patient-reported outcome measures …

Randomised controlled trials remain the reference standard for healthcare research on
effects of interventions, and the need to report both benefits and harms is essential. The …

Abstract In May 2019, the International Scientific Association for Probiotics and Prebiotics
(ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the …

During the past decade, research has revealed that the vast community of micro-organisms
that inhabit the gut—known as the gut microbiota—is intricately linked to human health and …

Statement of problem Systematic reviews and meta-analyses have emerged as forerunners
of evidence-based dentistry, but assessing the quality of the available research is essential …

ABSTRACT A meta-analysis of positive psychology intervention (PPIs) studies was
conducted. PPIs were defined as interventions in which the goal of wellbeing enhancement …

The CONSORT 2010 statement provides minimum guidelines for reporting randomised
trials. Its widespread use has been instrumental in ensuring transparency in the evaluation …