Overcoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies
Multidrug resistance is a key determinant of cancer chemotherapy failure. One of the major
causes of multidrug resistance is the enhanced efflux of drugs by membrane ABC …
causes of multidrug resistance is the enhanced efflux of drugs by membrane ABC …
Osteosarcoma: cells‐of‐origin, cancer stem cells, and targeted therapies
Osteosarcoma (OS) is the most common type of primary solid tumor that develops in bone.
Although standard chemotherapy has significantly improved long‐term survival over the past …
Although standard chemotherapy has significantly improved long‐term survival over the past …
[HTML][HTML] Baicalin; a promising chemopreventive agent, enhances the antitumor effect of 5-FU against breast cancer and inhibits tumor growth and angiogenesis in …
Despite considerable advances in cancer treatment, chemotherapy remains a cornerstone
in breast cancer therapy. Therefore, reducing chemoresistance and adverse effects of …
in breast cancer therapy. Therefore, reducing chemoresistance and adverse effects of …
The combination of curcumin and 5-fluorouracil in cancer therapy
Y Wei, P Yang, S Cao, L Zhao - Archives of pharmacal research, 2018 - Springer
Fluorouracil (5-FU) alone or in combination with other therapeutic drugs has been widely
used for clinical treatment of various cancers. However, 5-FU-based chemotherapy has …
used for clinical treatment of various cancers. However, 5-FU-based chemotherapy has …
Novel molecular insights and new therapeutic strategies in osteosarcoma
Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and
poor overall prognosis mainly in children and adolescents. Identifying the molecular …
poor overall prognosis mainly in children and adolescents. Identifying the molecular …
[HTML][HTML] Diet-derived phytochemicals targeting colon cancer stem cells and microbiota in colorectal cancer
Colorectal cancer (CRC) is a fatal disease caused by the uncontrolled propagation and
endurance of atypical colon cells. A person's lifestyle and eating pattern have significant …
endurance of atypical colon cells. A person's lifestyle and eating pattern have significant …
Emerging importance of dietary phytochemicals in fight against cancer: role in targeting cancer stem cells
Recent years have seen an unpretending increase in research using dietary phytochemicals
for targeting cancer and cancer stem cells (CSCs) due to the limited efficacy of conventional …
for targeting cancer and cancer stem cells (CSCs) due to the limited efficacy of conventional …
Emerging importance of tyrosine kinase inhibitors against cancer: quo vadis to cure?
GLOBOCAN 2020 estimated more than 19.3 million new cases, and about 10 million
patients were deceased from cancer in 2020. Clinical manifestations showed that several …
patients were deceased from cancer in 2020. Clinical manifestations showed that several …
Traditional Chinese medicine targeting cancer stem cells as an alternative treatment for hepatocellular carcinoma
K Tang, S Du, Q Wang, Y Zhang, H Song - Journal of Integrative Medicine, 2020 - Elsevier
Hepatocellular carcinoma (HCC) is a prevalent and highly malignant cancer throughout the
world. Effective treatment of this disease is impeded by the high rate of metastasis …
world. Effective treatment of this disease is impeded by the high rate of metastasis …
[HTML][HTML] Novel carbazole-piperazine hybrid small molecule induces apoptosis by targeting BCL-2 and inhibits tumor progression in lung adenocarcinoma in vitro and …
Lung cancer is a type of deadly cancer and a leading cause of cancer associated death
worldwide. BCL-2 protein is considered as an imperative target for the treatment of cancer …
worldwide. BCL-2 protein is considered as an imperative target for the treatment of cancer …