Optical imaging of voltage and calcium in cardiac cells & tissues
Cardiac optical map** has proven to be a powerful technology for studying cardiovascular
function and disease. The development and scientific impact of this methodology are well …
function and disease. The development and scientific impact of this methodology are well …
Processing and analysis of cardiac optical map** data obtained with potentiometric dyes
JI Laughner, FS Ng, MS Sulkin… - American Journal of …, 2012 - journals.physiology.org
Optical map** has become an increasingly important tool to study cardiac
electrophysiology in the past 20 years. Multiple methods are used to process and analyze …
electrophysiology in the past 20 years. Multiple methods are used to process and analyze …
[HTML][HTML] In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment
Human-based computational modelling and simulation are powerful tools to accelerate the
mechanistic understanding of cardiac patho-physiology, and to develop and evaluate …
mechanistic understanding of cardiac patho-physiology, and to develop and evaluate …
A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms
A long-sought, and thus far elusive, goal has been to develop drugs to manage diseases of
excitability. One such disease that affects millions each year is cardiac arrhythmia, which …
excitability. One such disease that affects millions each year is cardiac arrhythmia, which …
Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy
Background—Several arrhythmogenic mechanisms have been inferred from animal heart
failure models. However, the translation of these hypotheses is difficult because of the lack …
failure models. However, the translation of these hypotheses is difficult because of the lack …
[HTML][HTML] Universal ventricular coordinates: A generic framework for describing position within the heart and transferring data
Being able to map a particular set of cardiac ventricles to a generic topologically equivalent
representation has many applications, including facilitating comparison of different hearts …
representation has many applications, including facilitating comparison of different hearts …
Human organotypic cultured cardiac slices: new platform for high throughput preclinical human trials
Translation of novel therapies from bench to bedside is hampered by profound disparities
between animal and human genetics and physiology. The ability to test for efficacy and …
between animal and human genetics and physiology. The ability to test for efficacy and …
Remodeling of calcium handling in human heart failure
Heart failure (HF) is an increasing public health problem accelerated by a rapidly aging
global population. Despite considerable progress in managing the disease, the …
global population. Despite considerable progress in managing the disease, the …
Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia
Rationale: β-Adrenergic receptor stimulation produces sarcoplasmic reticulum Ca2+
overload and delayed afterdepolarizations in isolated ventricular myocytes. How delayed …
overload and delayed afterdepolarizations in isolated ventricular myocytes. How delayed …
Targeting cardiomyocyte Ca2 homeostasis in heart failure
Improved treatments for heart failure patients will require the development of novel
therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca2+ …
therapeutic strategies that target basal disease mechanisms. Disrupted cardiomyocyte Ca2+ …