Breast cancer (BC) is a common cancer all over the world that affects women. BC is one of
the leading causes of cancer mortality in women, which today has decreased with the …

Simple Summary With ever-increasing incidence, breast cancer is considered a most
diagnosed type of cancer among women worldwide. Breast cancer arises through malignant …

Cancer is a multi-step process and requires constitutive expression/activation of
transcription factors (TFs) for growth and survival. Many of the TFs reported so far are critical …

Despite advances in breast cancer treatments and related 5-year survival outcomes,
metastatic breast cancer cures remain elusive. The current standard of care includes a …

Progesterone and progesterone receptors (PRs) are essential for the development and
cyclical regulation of hormone-responsive tissues including the breast and reproductive …

Uterine fibroids (UFs) are the most important benign neoplastic threat to women's health
worldwide, with a prevalence of up to 80% in premenopausal women, and can cause heavy …

It is known that estrogen stimulates growth and inhibits apoptosis through estrogen receptor
(ER)-mediated mechanisms in many cancer cell types. Interestingly, there is strong evidence …

Background Increased expression of the progesterone receptor membrane component 1
(PGRMC1) has been linked to multiple cancers, including breast cancer. Despite being a …

The functional role of progesterone receptor (PR) and its impact on estrogen signaling in
breast cancer remain controversial. In primary ER+ (estrogen receptor–positive)/PR+ human …

Breast cancer is a complex and multifactorial disease with a significant global impact.
Hormonal imbalance has emerged as a crucial factor in breast cancer development …