Carbapenem-Resistant Klebsiella pneumoniae: Virulence Factors, Molecular Epidemiology and Latest Updates in Treatment Options

T Karampatakis, K Tsergouli, P Behzadi - Antibiotics, 2023 - mdpi.com
Klebsiella pneumoniae is a Gram-negative opportunistic pathogen responsible for a variety
of community and hospital infections. Infections caused by carbapenem-resistant K …

Klebsiella pneumoniae carbapenemase variants: the new threat to global public health

L Ding, S Shen, J Chen, Z Tian, Q Shi… - Clinical microbiology …, 2023 - journals.asm.org
Klebsiella pneumoniae carbapenemase (KPC) variants, which refer to the substitution,
insertion, or deletion of amino acid sequence compared to wild bla KPC type, have reduced …

Colistin monotherapy versus combination therapy for carbapenem-resistant organisms

KS Kaye, D Marchaim, V Thamlikitkul, Y Carmeli… - NEJM …, 2022 - evidence.nejm.org
Background Pneumonia and bloodstream infections (BSI) due to extensively drug-resistant
(XDR) Acinetobacter baumannii, XDR Pseudomonas aeruginosa, and carbapenem …

Guidelines for the diagnosis, treatment, prevention and control of infections caused by carbapenem-resistant gram-negative bacilli

M Zeng, J ** into the future: overcoming pharmacokinetic/pharmacodynamic hurdles to optimize the treatment of severe difficult to treat-Gram-negative infections with …
M Gatti, F Pea - Expert Review of Anti-infective Therapy, 2023 - Taylor & Francis
Introduction The choice of best therapeutic strategy for difficult-to-treat resistance (DTR)
Gram-negative infections currently represents an unmet clinical need. Areas covered This …