The importance of 3D fibre architecture in cancer and implications for biomaterial model design
JC Ashworth, TR Cox - Nature Reviews Cancer, 2024 - nature.com
The need for improved prediction of clinical response is driving the development of cancer
models with enhanced physiological relevance. A new concept of 'precision biomaterials' is …
models with enhanced physiological relevance. A new concept of 'precision biomaterials' is …
Reciprocal interplay between fibrillar collagens and collagen-binding integrins: implications in cancer progression and metastasis
Cancers are complex ecosystems composed of malignant cells embedded in an intricate
microenvironment made of different non-transformed cell types and extracellular matrix …
microenvironment made of different non-transformed cell types and extracellular matrix …
Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing
Abstract 'Smart'bandages based on multimodal wearable devices could enable real-time
physiological monitoring and active intervention to promote healing of chronic wounds …
physiological monitoring and active intervention to promote healing of chronic wounds …
Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing
Biomaterial wound dressings, such as hydrogels, interact with host cells to regulate tissue
repair. This study investigates how crosslinking of gelatin-based hydrogels influences …
repair. This study investigates how crosslinking of gelatin-based hydrogels influences …
Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors
Z **ao, L Todd, L Huang, E Noguera-Ortega… - Nature …, 2023 - nature.com
The desmoplastic stroma in solid tumors presents a formidable challenge to
immunotherapies that rely on endogenous or adoptively transferred T cells, however, the …
immunotherapies that rely on endogenous or adoptively transferred T cells, however, the …
Senescent CAFs mediate immunosuppression and drive breast cancer progression
The tumor microenvironment (TME) profoundly influences tumorigenesis, with gene
expression in the breast TME capable of predicting clinical outcomes. The TME is complex …
expression in the breast TME capable of predicting clinical outcomes. The TME is complex …
Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment
Only a fraction of cancer patients benefits from immune checkpoint inhibitors. This may be
partly due to the dense extracellular matrix (ECM) that forms a barrier for T cells. Comparing …
partly due to the dense extracellular matrix (ECM) that forms a barrier for T cells. Comparing …
Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration
Directed migration by contact guidance is a poorly understood yet vital phenomenon,
particularly for carcinoma cell invasion on aligned collagen fibres. We demonstrate that for …
particularly for carcinoma cell invasion on aligned collagen fibres. We demonstrate that for …
Self-generated gradients steer collective migration on viscoelastic collagen networks
Growing evidence suggests that the physical properties of the cellular microenvironment
influence cell migration. However, it is not currently understood how active physical …
influence cell migration. However, it is not currently understood how active physical …
Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting
Burns and other traumatic injuries represent a substantial biomedical burden. The current
standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which …
standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which …