The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

Down syndrome (also known as trisomy 21) is the model human phenotype for all genomic
gain dosage imbalances, including microduplications. The functional genomic exploration of …

The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …

GATA family proteins play essential roles in development of many cell types, including
hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3 …

The concept that some childhood malignancies arise from postnatally persistent embryonal
cells has a long history. Recent research has strengthened the links between driver …

Children with constitutional trisomy 21 (Down syndrome (DS)) have a unique predisposition
to develop myeloid leukaemia of Down syndrome (ML-DS). This disorder is preceded by a …

Transient abnormal myelopoiesis (TAM), a preleukemic disorder unique to neonates with
Down syndrome (DS), may transform to childhood acute myeloid leukemia (ML-DS) …

Abstract Gain of chromosome 21 (Hsa21) is among the most frequent aneuploidies in
leukemia. However, it remains unclear how partial or complete amplifications of Hsa21 …

Down syndrome is the most common chromosomal abnormality among live-born infants.
Through full or partial trisomy of chromosome 21, Down syndrome is associated with …

No major predisposition gene for familial myeloproliferative neoplasms (MPN) has been
identified. Here we demonstrate that the autosomal dominant transmission of a 700-kb …