Cell-free biology is the activation of biological processes without the use of intact living cells.
It has been used for more than 50 years across the life sciences as a foundational research …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …

Molecular diagnosis of COVID-19 primarily relies on the detection of RNA of the SARS-CoV-
2 virus, the causative infectious agent of the pandemic. Reverse transcription polymerase …

Functional nucleic acids (FNAs), including DNA aptamers and DNAzymes, are finding
increasing use as molecular recognition elements for point-of-care (POC) assays and …

Cell-based biosensors have great potential to detect various toxic and pathogenic
contaminants in aqueous environments. However, frequently they cannot meet practical …

Engineered RNA elements are programmable tools capable of detecting small molecules,
proteins, and nucleic acids. Predicting the behavior of these synthetic biology components …

Synthetic biology provides a new paradigm for life science research (“build to learn”) and
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …

While synthetic biology has revolutionized our approaches to medicine, agriculture, and
energy, the design of completely novel biological circuit components beyond naturally …

Recent advances in cell-free synthetic biology have given rise to gene circuit-based sensors
with the potential to provide decentralized and low-cost molecular diagnostics. However, it …

Synthetic biology has promoted the development of biosensors as tools for detecting trace
substances. In the past, biosensors based on synthetic biology have been designed on …