Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …

Functional nucleic acids (FNAs), including DNA aptamers and DNAzymes, are finding
increasing use as molecular recognition elements for point-of-care (POC) assays and …

Molecular diagnosis of COVID-19 primarily relies on the detection of RNA of the SARS-CoV-
2 virus, the causative infectious agent of the pandemic. Reverse transcription polymerase …

Cell-free biology is the activation of biological processes without the use of intact living cells.
It has been used for more than 50 years across the life sciences as a foundational research …

Cell-based biosensors have great potential to detect various toxic and pathogenic
contaminants in aqueous environments. However, frequently they cannot meet practical …

Engineered RNA elements are programmable tools capable of detecting small molecules,
proteins, and nucleic acids. Predicting the behavior of these synthetic biology components …

Synthetic biology provides a new paradigm for life science research (“build to learn”) and
opens the future journey of biotechnology (“build to use”). Here, we discuss advances of …

Early disease detection through point-of-care (POC) testing is vital for quickly treating
patients and preventing the spread of harmful pathogens. Disease diagnosis is generally …

Cell-free gene expression is a vital research tool to study biological systems in defined
minimal environments and has promising applications in biotechnology. Develo** …

Efforts to construct synthetic biological circuits with more complex functions have often been
hindered by the idiosyncratic behavior, limited dynamic range and crosstalk of commonly …