Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …

Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …

RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …

The regulation of gene expression is fundamental for life. Whereas the role of transcriptional
regulation of gene expression has been studied for several decades, it has been clear over …

METTL3 encodes the predominant catalytic enzyme to promote m6A methylation in nucleus.
Recently, accumulating evidence has shown the expression of METTL3 in cytoplasm, but its …

Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a
potential cancer therapeutic. However, the mechanisms underlying the initiation …

Summary N 7-methylguanosine (m 7 G) modification, routinely occurring at mRNA 5′ cap
or within tRNAs/rRNAs, also exists internally in messenger RNAs (mRNAs). Although m 7 G …

Summary N 6-methyladenosine (m 6 A), the most prevalent internal modification in
mammalian mRNAs, is involved in many pathological processes. METTL16 is a recently …

Background The molecular mechanisms driving hepatocellular carcinoma (HCC) remain
largely unclear. As one of the major epitranscriptomic modifications, N 6-methyladenosine …