Excessive adiposity raises blood pressure and accounts for 65–75% of primary
hypertension, which is a major driver of cardiovascular and kidney diseases. In obesity …

ABSTRACT CEACAM1 is an extensively studied cell surface molecule with established
functions in multiple cancer types, as well as in various compartments of the immune system …

Kidney function in metabolism is often underestimated. Although the word “clearance” is
associated to “degradation”, at nephron level, proper balance between what is truly …

The incidence of hypertension has increased to epidemic levels in the past decades.
Increasing evidence reveals that maternal dietary habits play a crucial role in the …

Importance Changes in kidney function are typically followed by the sequential estimation of
glomerular filtration rate (eGFR). Formulae for eGFR work well on a population basis, but …

The concept of local formation of angiotensin II in the kidney has changed over the last 10–
15 years. Local synthesis of angiotensinogen in the proximal tubule has been proposed …

Consuming a high-fat diet (HFD) is a risk factor for obesity and diabetes; both of these
diseases are also associated with systemic inflammation, similar to HIV infection. A HFD …

The (pro) renin receptor (PRR) is a multifunctional protein that is expressed in multiple
organs. Binding of prorenin/renin to the PRR activates angiotensin II–dependent and …

A link between inflammation with obesity and metabolic syndrome has been found in
patients with chronic kidney disease (CKD). Diacerein is an anthraquinone used to treat …

Standardized animal models represent one of the most valuable tools available to
understand the mechanism underlying the metabolic syndrome (MetS) and to seek for new …