Retinoic acid (RA) is a vital metabolite derived from vitamin A. RA plays a prominent role
during development, which helps in embryological advancement and cellular differentiation …

Peroxisome proliferator-activated receptors (PPARs) have been extensively studied for over
3 decades and consist of three isotypes, including PPARα, γ, and β/δ, that were originally …

Peroxisome-proliferator-activated receptors (PPARs) are nuclear hormone receptors
including PPARα, PPARδ and PPARγ, which play an important role in regulating cancer cell …

Abstract Blockade of PD-1/PD-L1 immune checkpoint could be an effective antitumor
strategy for multiple types of cancer, but it is low response rate for colorectal cancer patients …

Blockade of the programmed death 1 (PD‐1)/programmed death ligand 1 (PD‐L1) immune
checkpoint could increase antitumor immunotherapy for multiple types of cancer, but the …

As one of the peroxisome-proliferator-activated receptors (PPARs) members, PPARγ is a
ligand binding and activated nuclear hormone receptor, which is an important regulator in …

Calcium and cadmium are divalent metals and have similar chemical properties. Both can
enter cells through, albeit different, channels, or through protein-dependent permeation …

Abstract Blockade of PD-1/PD-L1 immune checkpoint is wildly used for multiple types of
cancer treatment, while the low response rate for patients is still completely unknown. As …

It is well known that the acquisition of chemoresistance is a major obstacle for the effective
treatment of human cancers. It is reported that microRNAs (miRNAs) are implicated in …

As a master transcription factor, c‐Myc plays an important role in promoting tumor immune
escape. In addition, PPARγ (peroxisome proliferator‐activated receptor γ) regulates cell …