An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

The human bone marrow (BM) niche sustains hematopoiesis throughout life. We present a
method for generating complex BM-like organoids (BMOs) from human induced pluripotent …

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …

Stroma is a poorly defined non-parenchymal component of virtually every organ with key
roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma …

Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and
metastasis through various mechanisms and is now recognized as a hallmark of cancer and …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

Our knowledge about the genetics of myelodysplastic syndromes (MDS) and related
myeloid disorders has been dramatically improved during the past decade, in which …

The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …